the results shown with objective tolerability assessments by the investigators supporting favorable tolerability with the skincare regimen.
The objective and subjective tolerability assessments based on mean scores are shown in Figure 5.
Subject Self-Perception Questionnaires (SPQ)
The results of the subject self-perception questionnaires were completed at multiple timepoints. Tables below depict the results at the end of study (12 weeks). As shown in Table 4A-B, the results were highly favorable.
Epidermal Hydration and Barrier Function Evaluation
A prospective study was completed on 20 White females evaluating corneometry and TEWL after a single application of CGCAM to dry forearm skin as compared to an untreated forearm site (control). A corneometer was used to test epidermal hydration at baseline, 1 hour, 8 hours, 24 hours, and 48 hours (Figure 6). Tewameter measurements reflecting TEWL were obtained at baseline, 1 hour, 8 hours, and 24 hours (Figure 7). The results of the above objective corneometry and TEWL studies support that CGCAM provides long-term significant epidermal hydration and sustains permeability barrier function.
CONCLUSION
Adjunctive skin care is an important component of acne management as it may enhance the therapeutic benefit and reduce the potential for skin tolerability reactions associated with acne therapy. The data reviewed in this manuscript support the use of a combined skincare regimen using a designated cleanser (CGCAC) and moisturizer (CGCAM). This skincare regimen was shown to improve mild acne with improvement in acne lesions and IGA. Skin tolerability was very favorable, and the regimen was well received among subjects.
