INTRODUCTIONPsoriasis is a chronic inflammatory condition affecting the skin.1,2 Pathophysiology involves Th1- and Th17-driven inflammation with consequently increased levels of TNF-α, IL-17, and IL-23.3 Patients with psoriasis are at increased…
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INTRODUCTIONRosacea is a chronic inflammatory facial skin condition characterized by episodic or persistent erythema, edema, telangiectasias, and/or inflammatory papules and pustules.1 The global prevalence of rosacea is approximately 5.46%, with…
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INTRODUCTIONGeneralized pustular psoriasis (GPP) is a rare, chronic, severe autoinflammatory dermatosis distinguished by abrupt flares of sterile pustulation, systemic inflammation, and substantial morbidity and mortality.1-4 Once viewed as a variant…
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In this issue:Generalized Pustular Psoriasis: A Contemporary Review of Diagnosis, Pathophysiology, and IL-36 Pathway–Directed ManagementGeneralized pustular psoriasis (GPP) is a rare, chronic, severe autoinflammatory dermatosis distinguished by abrupt flares of…
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INTRODUCTIONJanus kinase (JAK) inhibitors are increasingly prescribed for inflammatory and autoimmune diseases, including atopic dermatitis (AD), alopecia areata (AA), psoriasis/psoriatic arthritis (PsO/PsA), and inflammatory bowel disease (IBD).1-2 Their use has…
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INTRODUCTIONEczema is a prevalent, chronic skin condition with the highest burden among skin disorders globally, affecting approximately 20% of children and up to 10% of adults.1,2 The condition is characterized…
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INTRODUCTIONPatients are increasingly turning to social media for disease/treatment advice and support.1 This has varying benefits2 but involves the risk of inaccurate information.3,4 Reddit, a news/social content discussion platform site…
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INTRODUCTIONTirzepatide is a dual glucagon-like pedtide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) agonist and is primarily used to improve glycemic control along with weight reduction. It has also demonstrated anti-inflammatory…
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INTRODUCTIONAtopic dermatitis (AD) is a chronic inflammatory skin condition characterized by intense pruritus and recurrent flares.1 Despite advances in biologic therapies targeting key cytokines involved in AD, treatment challenges remain…
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INTRODUCTIONMedicare Part B spending on skin substitute products rose from $256 million in 2019 to more than $10 billion in 2024.1 A 2025 brief report first documented this trajectory in…
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INTRODUCTIONPsoriasis is a chronic inflammatory skin disorder known to be linked to type 2 diabetes mellitus (T2DM), with 11.6% of psoriasis patients having comorbid T2DM.1 Glucagon-like peptide-1 receptor agonists (GLP-1…
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Dear Editor, Psoriasis is recognized as a systemic disease with various comorbidities that increase disease burden and complicate treatment.1 Research has highlighted its systemic impacts, as well as worsened mental…
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