I thoroughly enjoyed reading the two articles by Drs. Emanuele and Spencer in your March Issue. The first article, “From DNA repair to proteome protection: new molecular insights for preventing…

INTRODUCTION Histopathologic examination of preoperative biopsy specimens remains paramount in terms of diagnosing melanoma. Rates of diagnosing melanoma accurately from a purely clinical basis leave much to be desired, with…

INTRODUCTIONBiobrane (Smith & Nephew, London, UK) is a biosynthetic wound dressing that has been widely used in burn treatment and as a skin graft donor site dressing.1,2 It has been…

INTRODUCTION Systemic lupus erythematosus (SLE) is the second most common autoimmune disorder amongst women of childbearing age after thyroid disease. SLE is challenging to manage as it affects the body…

The Psoriasis Area Severity Index (PASI) is the most commonly utilized and extensively validated tool to assess the severity of psoriasis and treatment effect, especially in clinical research.1,2 PASI quantitatively…

INTRODUCTION Psoriasis, eczema and other immune-mediated skin diseases arise in the context of cutaneous inflammation.1 The majority of treatments for these conditions target the effector arm of the immune response,…

INTRODUCTIONPolyacrylamide hydrogel is a non-degradable, well-characterized filler agent, which becomes intimately integrated with its surrounding host tissue through vessel-ingrowth.1 Aquamid® (Contura International A/S, Denmark) is a 2.5% polyacrylamide hydrogel that…

INTRODUCTIONUltraviolet (UV) radiation, a form of ionizing radiation, results in approximately 1.5 million disability-adjusted life years (DALYs) and is associated with greater than 60,000 deaths annually worldwide attributed to melanoma…

INTRODUCTIONCorticosteroids and TEWL Transepidermal water loss (TEWL) is a marker for epidermal barrier dysfunction that has been shown to independently correlate with atopic dermatitis severity.5 Although topical corticosteroids are frequently…

INTRODUCTIONVemurafenib is a BRAF kinase inhibitor that improves the survival of patients with metastatic melanoma with the V600E BRAF mutation. Vemurafenib received FDA approval in August 2011 for this use.1…

Eczema is a group of chronic relapsing inflammatory conditions, with atopic dermatitis being its most common form.1-4 Around 10% to 20% of children are affected by atopic dermatitis, which also…

BACKGROUND Necrobiotic xanthogranuloma (NXG) is a rare, granulomatous disorder of unknown etiology that often presents as firm plaques and nodules with a yellow-brown to red coloration. First described by Kossard…