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Dec 10
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Epigenetics in the Pathogenesis and Pathophysiology of Psoriasis Vulgaris

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INTRODUCTIONThe role of genetics in the development of psoriasis has been recognized for more than six decades.1 Psoriasis harbors a significant heritable component that is wellestablished, and a family history…
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Dec 10
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Management of Cutaneous Abscesses by Dermatologists

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INTRODUCTION Skin and soft tissue infections (SSTIs) are generally uncomplicated at the time of initial presentation. However, these infections can worsen quickly when there are delays in presentation and treatment.…
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Dec 10
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Spironolactone and Topical Retinoids in Adult Female Cyclical Acne

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INTRODUCTIONSpironolactone was developed as a mineralocorticoid receptor antagonist following the observation that spirolactones block the effect of mineralocorticoids in the late 1950’s. The resulting increase in salt and water excretion…
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Dec 10
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Therapeutic Implications of the Circadian Clock on Skin Function

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INTRODUCTION Our circadian rhythm is an endogenous timing system generated from the body’s central pacemaker, the suprachiasmatic nucleus (SCN). Located in the hypothalamus and superior to the optic chiasm, its…
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Dec 10
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Pilot Randomized-Control Trial to Assess the Effect Product Sampling has on Adherence Using Adapalene/Benzoyl Peroxide Gel in Acne Patients

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INTRODUCTIONAcne is a common condition, which affects most people at some point in their lifetime, including approximately 85% of adolescents.1 In addition to physical effects of acne, such as potential…
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Dec 10
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Ciclopirox vs Amorolfine: In Vitro Penetration Into and Permeation Through Human Healthy Nails of Commercial Nail Lacquers

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INTRODUCTIONOnychomycosis is a nail disease, which affects a high percentage of adult population and presents many difficulties in treatment management.1-3 The therapy consists mainly in broad-spectrum antimycotic agents administered via…
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Dec 10
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Role of Oral Polypodium Leucotomos Extract in Dermatologic Diseases: A Review of the Literature

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INTRODUCTION Polypodium leucotomos is a tropical fern of the Polypodiaceae family native to Central and South America. Polypodium leucotomos extract (PLE; Fernblock®, Ferndale Laboratories, Ferndale, Michigan, USA) is a polyphenol-enriched…
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Dec 10
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Efficacy and Safety of Ingenol Mebutate 0.015% Gel 3 Weeks After Cryosurgery of Actinic Keratosis: 11-Week Results

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INTRODUCTIONActinic keratosis (AK) is considered by some as the earliest stage of squamous-cell carcinoma. It is capable of progressing to in situ or invasive squamous-cell carcinoma, and is prevalent in…
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Dec 10
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Use of Naftifine Hydrochloride 2% Cream and 39% Urea Cream in the Treatment of Tinea Pedis Complicated by Hyperkeratosis

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INTRODUCTIONTinea pedis is the most commonly encountered superficial cutaneous fungal infection in humans. In the United States, the highly contagious Trichophyton rubrum and Trichophyton mentagrophytes Var interdigitale are recognized as…
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Dec 10
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Imiquimod 2.5% and 3.75% for the Treatment of Actinic Keratoses: Two Phase 3,Multicenter, Randomized, Double-Blind, Placebo-Controlled Studies

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INTRODUCTION Actinic keratosis (AK) is one of the most common skin conditions seen in dermatological practice.1 From 2000 to 2003, there were an estimated 5.2 million physician visits annually in…
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Dec 10
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A Subgroup Analysis to Evaluate the Efficacy and Safety of Adapalene-Benzoyl Peroxide Topical Gel in Black Subjects With Moderate Acne

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INTRODUCTIONAcne vulgaris is a common, easily recognized skin condition that affects adolescents and adults in all races and ethnicities. In published single-center and national practice surveys, acne vulgaris was the…
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Dec 10
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The Prophylactic Use of a Topical Scar Gel Containing Extract of Allium Cepae, Allantoin, and Heparin Improves Symptoms and Appearance of Cesarean-Section Scars Compared With Untreated Scars

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INTRODUCTIONCesarean section (C-section) is one of the most common abdominal operations performed on women and the incidence of this procedure has increased dramatically in recent years, comprising 20–25% of all…
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