Optimizing the Trial Design for a Comparative Effectiveness Study of Spironolactone versus Oral Antibiotics for Women With Acne: A Delphi Consensus Panel

December 2020 | Volume 19 | Issue 12 | Editorials | 1238 | Copyright © December 2020


Published online November 3, 2020

John S. Barbieri MD MBA,a David J. Margolis MD PhDa,b

aDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
bDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA


DISCLOSURES

The authors have no conflicts to declare.

Funding/Support: This study was supported National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number R34-AR074733-01A1. Dr. Barbieri is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award numberT32-AR-007465 and receives partial salary support through a Pfizer Fellowship in Dermatology Patient Oriented Research grant to theTrustees of the University of Pennsylvania.

Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

REFERENCES

  1. Collier CN, Harper JC, Cafardi JA, et al. The prevalence of acne in adults 20 years and older. J Am Acad Dermatol. 2008;58(1):56-59.
  2. Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945-973. e33.
  3. Barbieri JS, James WD, Margolis DJ. Trends in prescribing behavior of systemic agents used in the treatment of acne among dermatologists and nondermatologists: A retrospective analysis, 2004-2013. J Am Acad Dermatol. 2017;77(3):456-463.e4.
  4. Barbieri JS, Choi JK, Mitra N, Margolis DJ. Frequency of treatment switching for spironolactone compared to oral tetracycline-class antibiotics for women with acne: a retrospective cohort study 2010-2016. J Drugs Dermatol JDD. 2018;17(6):632-638.
  5. Barbieri JS, Spaccarelli N, Margolis DJ, James WD. Approaches to limit systemic antibiotic use in acne: Systemic alternatives, emerging topical therapies, dietary modification, and laser and light-based treatments. J Am Acad Dermatol. October 2018.
  6. Layton A, Eady EA, Peat M, et al. Identifying acne treatment uncertainties via a James Lind Alliance Priority Setting Partnership. BMJ Open. 2015;5(7):e008085.
  7. Prioritization CoCER. Initial National Priorities for Comparative Effectiveness Research. Washington, DC: National Academies Press; 2009. https://www. ncbi.nlm.nih.gov/books/NBK64788/. Accessed December 23, 2017.
  8. Boulkedid R, Abdoul H, Loustau M, Sibony O, Alberti C. Using and reporting the Delphi method for selecting healthcare quality indicators: a systematic review. PloS One. 2011;6(6):e20476.

AUTHOR CORRESPONDENCE

John Barbieri MD MBA john.barbieri@pennmedicine.upenn.edu
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