and amorphous elastin clumps. To this end phosphatidylserine (PS), a highly enriched membrane phospholipid component, is known to have several physiological roles, such as activating
signaling enzymes and antioxidant activity.34 It has been found to decrease MMP-1 in a dose dependent manner, to increase procollagen formation and may act as a substrate for AGE targets thus reducing the damage from glycation effects.
11,34,35 Clearance of apoptotic cells is necessary for tissue development, homeostasis, and resolution of inflammation. PS provides an “eat me†signal on the cell surface, and phagocytes recognize the signal using specific receptors such as the receptor
of advanced glycation end products (RAGE). This then binds to PS and assists in the clearance of apoptotic cells and end products of AGE.35
As described above, one of the main processes responsible for cellular and extracellular aging is the accumulation of damaged proteins in the cell and the ECM. The ECM proteins
are subject to various abnormal post-translational modifications such as oxidation, glycation and conjugation
with products from lipid peroxidation, and proteasome dysfunction, all of which may be associated with aging and hastened by UV irradiation. The accumulation of damaged proteins can affect the efficacy of the proteolytic systems, including extracellular MMPs, cytokines, anti-oxidants, and
the intracellular proteasomal system, that are responsible for eliminating damaged proteins.
Alastin TriHex Technologyâ„¢
By combining this group of potent peptides, lipids, and botanicals,
a sequential ECM modulation range (Alastin SkinCare Inc, Carlsbad, CA) has been formulated to aid in clearing and regenerating the ECM (Figure 4). This formulation, designed with specific solubilizing moieties, facilitates rapid skin penetration
and provides good compatibility with non-aqueous formulations.
Thus Alastin Regenerating Skin Nectarâ„¢ with TriHex Technology
™ utilizes innovative peptide technology to support matrix remodeling optimizing the skin both pre- and postprocedure. This “skin bed preparation†improves skin responsiveness to treatment and after treatment, strengthens any compromised tissue, and minimizes post-treatment side effects.
As with all therapeutic dermatologic preparations, the skin penetration
and absorption is critical to efficacy of any product. In that regard, the tripeptide, hexapeptide, phosphatidylserine, and oleuropein are suspended in a proprietary, non-aqueous conjugate - like delivery system within a silicone elastomer gel designed specifically to deliver rapid penetration of the
