Expert Recommendations on the Use of Injectable Poly-L-lactic Acid for Contour Deficiencies of the Buttocks

January 2022 | Volume 21 | Issue 1 | Original Article | 21 | Copyright © January 2022


Published online December 30, 2021

Justin Harper MD,a Luiz Eduardo Avelar MD,b Alessandra Haddad MD PhD,c Juliana Cunha Sarubi Novello MD,d Douglas Mest MD,e Christine Guarnieri-Munia MD,f Sean Rice MD,g Janelle Vega MD,h Bill Andriopoulos PhD,i Alessandra Nogueira MD,j Neil Sadick MDk

aJuvly Aesthetics, Columbus, OH
bClinica Luiz Avelar, Belo Horizonte, Brazil
cFederal University of São Paulo, Brazil
dPrivate Practice, Belo Horizonte, MG, Brazil
ePier Medical Aesthetics, Hermosa Beach, CA
fCentro de Dermatologia, São Paulo, Brazil
gPractice, Toronto, Ontario, Canada
hMayoral Dermatology, Miami, FL
iGalderma Aesthetics, Uppsala, Sweden
jGalderma Laboratories, L.P., Fort Worth, TX
kWeill Medical College of Cornell University, New York; Sadick Dermatology, New York, NY

Abstract
Poly-L-lactic acid (PLLA) is an injectable biodegradable biostimulator that promotes collagen production and is approved for use in aesthetic facial augmentation. PLLA is well tolerated with minimal downtime and has demonstrated an excellent safety profile, as well as a longevity benefit of at least 2 years following injection. The robust safety and efficacy profile associated with PLLA for facial rejuvenation has resulted in a growing interest in the use of PLLA for other body areas such as the buttocks, which are an increasingly popular target of aesthetic enhancement. Patient goals for gluteal enhancement include improving contour and texture, reduction in visible cellulite and increased volume and lift. In order to achieve optimal outcomes and patient satisfaction, it is essential to ensure correct usage of PLLA; however, there is currently a lack of guidelines and expert recommendations in this area. This report reflects consensus recommendations for the use of PLLA in non-invasive buttock contouring, including patient selection, PLLA preparation, dosing, injection and, efficacy and safety assessments. Recommendations were provided by the collective author group, comprising international leaders in the field of aesthetics, dermatology, and plastic surgery.

J Drugs Dermatol. 2022;21(1):21-26. doi:10.36849/JDD.6180

INTRODUCTION

Poly-L-lactic acid (PLLA) is an injectable biodegradable biostimulator that promotes collagen production.1 PLLA has been shown to induce an inflammatory response whereby the injected microparticles are encapsulated by host immune cells which in turn stimulate neocollagenesis,1 gradually generating new volume and structural support at the site of injection.1,2

PLLA has been approved for facial aesthetic use in Europe since 1999 and in the US since 2009.3 It has also been used therapeutically for decades in suture materials, dissolvable meshes used in orthopedics, and medical implants.2,4 The safety and efficacy of PLLA for facial rejuvenation has been widely demonstrated and there is now a growing interest in the use of PLLA for other body areas outside the face, including the arms, chest, and buttocks.3,5–8

The buttocks are a particular area of interest, with gluteal aesthetics becoming an increasingly common patient concern. Patient goals for buttock enhancement include improved contour and texture, reduction in visible cellulite, and increased volume and lift.7 PLLA has demonstrated significant increases in gluteal skin thickness and improvements in sagging and skin texture.9 Whilst guidelines exist for facial rejuvenation using PLLA,3,10 there is a lack of recommendations on the use of PLLA for the buttocks. Ensuring correct usage of PLLA is essential to achieve optimal patient outcomes and satisfaction when treating the buttocks. Moreover, a need also exists for