responder rate at month 3 was significantly greater in the HASHA group compared with the no-treatment control group (83.3% vs 10.8%; P<0.001; Table 2). The GCRS responder rate remained significantly greater in the HASHA group compared with the no-treatment group from month 6 (80% vs 6%; P<0.001) through month 12 (66% vs 3%; P<0.001) (Figure 1). Subgroup analyses based on injection volume (greater than or less than/equal to 2.8 mL [median volume]) showed similar treatment effects as observed for the full study population (Table 3).
Global Aesthetic Improvement
Aesthetic improvement on the GAIS was achieved in high proportions of subjects, 97% or greater and 89% or greater as assessed by the treating investigator and subjects, respectively, from month 1 through month 12 after treatment with HASHA (Figure 2).
Subject Satisfaction
Overall, subject satisfaction was high through month 12, as per the subject satisfaction questionnaire (Figure 3). From month 3 to month 12 post-treatment, subjects in the HASHA group were satisfied/very satisfied with the shape of their chin (range: 87% to 93%), the projection of their chin (range: 87% to 94%), and their chin profile (range: 82% to 93%). From month 3 to month 12 post-treatment, subjects in the HASHA group agreed/strongly agreed that their chin looked natural (range: 95% to 96%), made them feel more attractive (range: 71% to 73%), improved their overall satisfaction with their appearance (range: 81% to 92%), and made them feel better about themselves (range: 77% to 79%). A high proportion of subjects who received HASHA said they would receive the treatment again (range: 80% to 84%) and would recommend the treatment to a friend (range: 92% to 97%).
