Stacy R. Smith MD,a Shuai Xu MD MS,b Esther Estes MD MPH,c Stuart D. Shanler MD FAAD FACMSc
aCalifornia Dermatology and Clinical Research Institute, Encinitas, CA bNorthwestern University Feinberg School of Medicine, Chicago, IL cAclaris Therapeutics, Inc., Wayne, PA
ties, and all vesiculations completely resolved within a week. Longer-term concerns—hyperpigmentation, hypopigmentation, and scarring—occurred at low rates at day 106 regardless of anatomic location, with the lowest rates observed on the facial SKs (2.3%, 1.9%, and 0%, respectively (Table 3).
SKs can be disturbing to patients, particularly when present on aesthetically sensitive areas such as the face.9,10 Currently, there are several physical methods for removing SKs that include surgical excision, curettage, electrosurgery, ablative lasers, and cryosurgery.6 However, these modalities may require specialized training and lack well-controlled clinical trials demonstrating overall efficacy and complication rates.9,10 These destructive techniques may cause pain lasting beyond the treatment, require anesthesia, or pose risk of post-procedural adverse reactions. Cryosurgery with liquid nitrogen is the most popular method, but the efficacy of this modality depends on specialized training such as balancing adequate freeze time and
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