Amantadine-Induced Livedo Reticularis: A Report of Two Cases
March 2006 | Volume 5 | Issue 3 | Case Reports | 288 | Copyright © March 2006
Benjamin B. Hayes MD PhD, Robert H. Cook-Norris BS, Jami L. Miller MD, Adrian Rodriguez MD, John A. Zic MD
In the last several years, amantadine has been increasingly prescribed for akinesia in Parkinson’s disease and to combat
fatigue associated with multiple sclerosis. Amantadine is a well-known medication involved in drug-induced livedo reticularis
(LR),1 yet remains under-reported in the English literature. We describe 2 patients with amantadine livedo reticularis:
one patient with multiple sclerosis had, previous to this eruption, tolerated 4 years of amantadine therapy without adverse
reactions and another patient with Parkinson’s disease who developed LR 1 month after starting amantadine.