Amantadine-Induced Livedo Reticularis: A Report of Two Cases

In the last several years, amantadine has been increasingly prescribed for akinesia in Parkinson’s disease and to combat fatigue associated with multiple sclerosis. Amantadine is a well-known medication involved in drug-induced livedo reticularis (LR),1 yet remains under-reported in the English literature. We describe 2 patients with amantadine livedo reticularis: one patient with multiple sclerosis had, previous to this eruption, tolerated 4 years of amantadine therapy without adverse reactions and another patient with Parkinson’s disease who developed LR 1 month after starting amantadine.