are already predisposed to vasoactive instability.9 Providers should inform patients who consume ethanol of this potential reaction before starting tacrolimus therapy. Future studies are needed to determine whether this adverse effect occurs more frequently in patients with rosacea.
DISCLOSURES
The authors have no conflicts of interest to disclose.
REFERENCES
1. Knight AK, Boxer M, Chandler MJ. Alcohol-induced rash caused by topical tacrolimus. Ann Allergy Asthma Immunol. 2005;95(3):291-292.
2. Soter NA, Fleischer AB, Jr., Webster GF, et al. Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part II, safety. J Am Acad Dermatol. 2001;44(1 Suppl):S39-46.
3. Ehst BD, Warshaw EM. Alcohol-induced application site erythema after topical immunomodulator use and its inhibition by aspirin. Arch Dermatol. 2004;140(8):1014-1015.
4. Ständer S, Ständer H, Seeliger S, Luger TA, Steinhoff M. Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin. Br J Dermatol. 2007;156(5):1020-6.
5. Milingou M, Antille C, Sorg O, Saurat JH, Lübbe J. Alcohol intolerance and facial flushing in patients treated with topical tacrolimus. Arch Dermatol. 2004;140(12):1542-4.
6. Sabater-Abad J, Matellanes-Palacios M, Millán Parrilla F. Image gallery: interaction between alcohol and topical tacrolimus as a cause of facial flushing. Br J Dermatol. 2019;180(5):e144.
7. Bamford JT, Elliott BA, Haller IV. Tacrolimus effect on rosacea. J Am Acad Dermatol. 2004;50(1):107-108.
8. Goldman D. Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report. J Am Acad Dermatol. 2001;44(6):995-998.
9. Antille C, Saurat JH, Lübbe J. Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment. Arch Dermatol. 2004;140(4):457-460.
2. Soter NA, Fleischer AB, Jr., Webster GF, et al. Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part II, safety. J Am Acad Dermatol. 2001;44(1 Suppl):S39-46.
3. Ehst BD, Warshaw EM. Alcohol-induced application site erythema after topical immunomodulator use and its inhibition by aspirin. Arch Dermatol. 2004;140(8):1014-1015.
4. Ständer S, Ständer H, Seeliger S, Luger TA, Steinhoff M. Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin. Br J Dermatol. 2007;156(5):1020-6.
5. Milingou M, Antille C, Sorg O, Saurat JH, Lübbe J. Alcohol intolerance and facial flushing in patients treated with topical tacrolimus. Arch Dermatol. 2004;140(12):1542-4.
6. Sabater-Abad J, Matellanes-Palacios M, Millán Parrilla F. Image gallery: interaction between alcohol and topical tacrolimus as a cause of facial flushing. Br J Dermatol. 2019;180(5):e144.
7. Bamford JT, Elliott BA, Haller IV. Tacrolimus effect on rosacea. J Am Acad Dermatol. 2004;50(1):107-108.
8. Goldman D. Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report. J Am Acad Dermatol. 2001;44(6):995-998.
9. Antille C, Saurat JH, Lübbe J. Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment. Arch Dermatol. 2004;140(4):457-460.
AUTHOR CORRESPONDENCE
Elisabeth A. George Elisabeth_george@brown.edu
