The Current Landscape of Treatment of Warts

December 2025 | Volume 24 | Issue 12 | 9099 | Copyright © December 2025


Published online November 25, 2025

Paige Oden BSa, Sandra Marchese Johnson MD FAADb

aUniversity of Arkansas for Medical Sciences College of Medicine, Little Rock, AR
bJohnson Dermatology, Fort Smith, AR

Abstract
Warts have bothered people since the early Greek and Roman empires.5 For centuries, people have studied causes of and treatments for these irritating tumors. In recent history, treatments have stagnated. Warts are caused by non-enveloped, circular, double-stranded DNA human papillomavirus (HPV).6 Most infections are subclinical, but clinically relevant disease ranges from warts to invasive carcinoma.6 Two-thirds of warts resolve spontaneously within 2 years, meaning that the stakes for treatments are high.4 Successful therapies need to have high resolution, few side effects, and act fast. The lack of radical antiviral HPV treatment represents a significant care gap. Although common warts are generally due to low-risk HPV strains, coinfection with higher-risk variants is not uncommon.

 

INTRODUCTION

What Are Warts?
Warts are papillomas arising from HPV infection of epidermal or mucosal cells. Histologically, warts demonstrate epidermal hyperplasia, parakeratosis, koilocytosis, and papillomatosis. Reasons for treatment include pain, functional impairment, transmission risk, and cosmetic embarrassment.18 Presenting patients may represent an infected population, so measures inhibiting spread, such as socks covering affected feet, are beneficial.4 There are several types of skin/cutaneous and submucosal warts. Cutaneous warts can be further subdivided. Verruca vulgaris (Figure 1), or common warts, often appear as hyperkeratotic papules and plaques.4 Plantar warts (Figures 2, 5)
are thick, painful hyperkeratotic plaques, often beneath pressure points on the plantar aspect of the foot.4 They look similar to corns, but corns do not exhibit pinpoint bleeding upon paring, and preserve skin markings.4 Periungual warts (Figure 6) are found around or under the nail beds, particularly in people who bite their nails.4 Finally, planar warts (Figure 4) appear as flat-topped papules, particularly on women's faces or legs.