MATERIALS AND METHODS
The consensus project used a modified Delphi process comprising face-to-face (February 10, 2023) discussions followed-up online.9 The process entailed preparing the project, selecting the panel, and conducting systematic literature searches to inform 15 draft statements.9 During the meeting, the panel evaluated the draft statements during a workshop. Then, a plenary discussion adopted 5 statements to provide clinical data for pediatric dermatologists, dermatologists, and pediatric healthcare providers.
Systematic Literature Searches
The scope of the literature search comprises the attenuation of AD for newborns, infants, and children and the role of skin care, such as ceramide-containing skin care as a monotherapy or as an adjunct to prescription topical and systemic medication.
The literature review considered clinically relevant materials published in English between January 2010 and December 20, 2022, including randomized controlled trials, other clinical studies, guidelines, consensus papers, and review articles. Systematic literature searches on PubMed and Google Scholar (secondary source) were conducted on December 20-22, 2022, by a researcher/clinician (HA) and a physician/scientist (AA).
Search terms are provided in Table 1. First, titles and abstracts were reviewed, followed by the full article. The 2 reviewers evaluated results independently, and selected publications were graded based on reviewer consensus.
Each selected clinical publication that included skincare information was graded (A, B, or C for study type and 1-4 for likelihood to change confidence in the effect shown).9
The 194 studies that met the quality criteria of the literature search informed the creation of 15 draft messaging statements to guide the development of a manuscript. After the panel discussions and online follow-up, a further 152 articles were excluded, leaving n=42 (Figure 1).
