Assessment of the Interference of Hyperdiluted Calcium Hydroxyapatite for Neck Rejuvenation in the Ultrasonographic Evaluation of Thyroid

November 2022 | Volume 21 | Issue 11 | 1243 | Copyright © November 2022


Published online October 28, 2022

doi:10.36849/JDD.6877

Gladstone Eustaquio de Lima Faria MAa, Alyne Queiroga Bastos MDa, Clarissa Lima Vilela MDa, Luciana Zattar MDa, Ricardo Frota Boggio PhDa

aInstituto Boggio, São Paulo, Brazil

Abstract
Background: Sagging neck skin is a common complaint, and the use of calcium hydroxyapatite injection is a traditional treatment approach for this region. The published literature is limited concerning the possible interference in imaging exams of hyperdiluted product, which presents radiopaque features, for the assessment of deep structures to the application.
Objective: To assess possible interferences in the ultrasonographic evaluation of thyroid after application of hyperdiluted CaHA on the neck region.
Methods: This was a prospective, blinded, and controlled study. Patients had their cervical regions treated with diluted CaHA (1:4). Ultrasonographic evaluations of thyroid were conducted on day 0 (pre-procedure), day 15, and day 60 by two radiologists blinded to the application.
Results: On day 0 no exclusion criteria were observed. On day 15 technical artifacts that difficulted the evaluation but did not make the complete assessment of the thyroid unable, were seen. On day 60 the artifacts of posterior acoustic shadowing were considerably reduced, not bringing any difficulty whatsoever for evaluation of the gland.
Conclusion: Treatment of sagging neck skin with diluted CaHA in 1:4 does not negatively impact the ultrasonographic evaluation of the thyroid as early as 15 days, and particularly after 60 days from the procedure.

J Drugs Dermatol. 2022;21(11):1243-1248. doi:10.36849/JDD.6877

INTRODUCTION

Cervical region is strongly impacted by the aging process that may progress with skin atrophy, accumulation of submental fat, wrinkles, loss of contour, and sagging skin. Among so many changes in this region, sagging skin is unquestionably one of the most impactful. For this reason, the treatment designed to stimulate the production of collagen in this region has stood out.1

One of the major allies in the prevention and treatment of this region are the injectable biostimulators and, among these biostimulators, the calcium hydroxyapatite is highlighted. Its biostimulatory ability of activating fibroblasts leads to the production of type 1 collagen, elastin, and proteoglycans in addition to improving the skin elasticity and thickness.2

The growing demand for minimally invasive procedures, along with the anatomical complexity of the cervical region, is followed by the increase in complications rate, as well as by a concern regarding the possible interference of these products in the assessment of underlying structures of the skin planning on the neck.

The great question regarding the use of calcium hydroxyapatite on the neck is whether the calcium component of the product and its radiopaque features could negatively impact the assessment of underlying structures after the treatment, such as the thyroid gland.

On ultrasound examination, undiluted calcium hydroxyapatite manifests as hyperechogenic deposits with posterior acoustic shadowing3 (Figure 1), which may limit the evaluation of