Amantadine-Induced Livedo Reticularis: A Report of Two Cases

March 2006 | Volume 5 | Issue 3 | Case Reports | 288 | Copyright © March 2006

Benjamin B. Hayes MD PhD, Robert H. Cook-Norris BS, Jami L. Miller MD, Adrian Rodriguez MD, John A. Zic MD

In the last several years, amantadine has been increasingly prescribed for akinesia in Parkinson’s disease and to combat fatigue associated with multiple sclerosis. Amantadine is a well-known medication involved in drug-induced livedo reticularis (LR),1 yet remains under-reported in the English literature. We describe 2 patients with amantadine livedo reticularis: one patient with multiple sclerosis had, previous to this eruption, tolerated 4 years of amantadine therapy without adverse reactions and another patient with Parkinson’s disease who developed LR 1 month after starting amantadine.