Algorithm to Improve Patient Comfort and Treat Diabetes Mellitus-Related Xerosis

April 2023 | Volume 22 | Issue 4 | 356 | Copyright © April 2023


Published online March 23, 2023

Robert S. Kirsner MD PhDa, Anneke Andriessen PhDb, Jason R. Hanft DPM FACFASc, Shasa Hu MD FAADa,d, Lee C. Ruotsi MD ABWMS CWS-P UHMe, Gil Yosipovitch MD FAADa,f

aDr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL
bRadboud UMC Nijmegen, Andriessen Consultants, Malden, The Netherlands
cPodiatric Surgery Specialist, Foot & Ankle Institute of South Florida, South Miami, FL; South Miami Hospital, South Miami, FL
dDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Sylvester Comprehensive Cancer Center, Miami, FL
eSaratoga Hospital Center for Wound Healing and Hyperbaric Medicine, Saratoga Springs, NY
fMiami Itch Center, Miami, FL

Abstract
Background: Diabetes mellitus (DM)-related cutaneous disorders such as xerosis frequently occur in patients with type 1 and type 2 diabetes. Gentle cleansers and moisturizers are underused to prevent xerosis or provide effective early treatment and maintenance.
Methods: The project used a modified Delphi hybrid process comprising face-to-face discussions followed by an online review process. A panel of physicians who treat patients with diabetes with DM used information from literature searches coupled with expert opinions and their experience to develop a practical algorithm to improve outcomes for patients with DM-related xerosis.
Results: The algorithm for DM-related xerosis aims to inform dermatologists and other health care professionals caring for patients with DM. The first section of the algorithm addresses education and behavioral measures. Treatment adherence is a considerable challenge in people with DM, making education essential. The second section discusses the assessment of the skin condition. The third section reports on an interdisciplinary team-based approach to patients with DM-related xerosis. The algorithm describes treatment and maintenance approaches using cleansers and moisturizers for mild, moderate, and severe xerosis, distinguishing between the body, face, hands, and feet.
Conclusion: The algorithm supports educating health care professionals and patients on xerosis prevention and treatment using ceramides-containing gentle cleansers and moisturizers to improve patient comfort and prevent complications.

J Drugs Dermatol. 2023;22(4): doi:10.36849/JDD.7177

Citation: Kirsner RS, Andriessen A, Hanft JR, et al. Algorithm to improve patient comfort and treat diabetes mellitus-related xerosis. J Drugs Dermatol. 2023;22(4):356-363. doi:10.36849/JDD.7177

INTRODUCTION

Diabetes mellitus (DM) type 1 (DM-1) and type 2 (DM-2) is a worldwide public health problem affecting over 460 million people globally in 2019; and estimated to rise to 578 million and 700 million by 2030 and 2045, respectively.1 The high prevalence of DM and its complications put pressure on global health expenditures, which in 2017 were estimated to be over 7 billion USD with around 4 million DM-related deaths.2

Due to an unknown cause, the pancreas of DM-1 patients produces insufficient insulin leading to elevated blood glucose levels.3 Over time, DM-1 may lead to severe damage to the heart, blood vessels, eyes, kidneys, and nerves.3-5 DM-2 occurs due to the body’s ineffective use of insulin. It comprises most patients with DM and is primarily the result of excess body weight and physical inactivity.3-5 Among existing diabetes incidence data, a few studies suggest that diabetes incidence could be falling despite rising or stable prevalence, but data are inconsistent.5,6

Between 30% and 70% of patients with DM, both type 1 and type 2, present with DM-related cutaneous diseases.7,8-15 Studies on DM-related skin conditions are limited and typically focus on diabetic foot syndrome and diabetic foot ulcers.10-14 The severity of DM-related cutaneous disease may vary, ranging from benign to deforming to life-threatening.13 Diabetic skin changes may allow insight into patients’ glycemic control and may be the first signs of DM in undiagnosed patients.8,11,12,15 Recognition and management of DM-related skin conditions are important in maximizing patients’ quality of life (QoL) and in avoiding severe complications.11,13,15-17

Maintaining an intact skin barrier by preventing and treating xerosis using gentle cleansers and moisturizers may improve skin conditions in patients with diabetes.11,13,15-17 Currently, gentle cleansers and moisturizers are underused.11 Skincare is frequently lacking or overlooked as part of DM patients’ skin