Found 286 articles for: "biologics"
A Multicenter, Randomized, Double-Blind Study of the Efficacy and Safety of Calcipotriene Foam, 0.005%, vs Vehicle Foam in the Treatment of Plaque-type Psoriasis of the Scalp
March 2013 | Volume 12 | Issue 3 | Original Article | 300 | Copyright © March 2013
BACKGROUND: Calcipotriene ointment and cream are effective treatments for psoriasis, but many patients with scalp psoriasis prefer lighter, less messy vehicles.
OBJECTIVES: To evaluate the effic...
Read MorePipeline Previews
February 2013 | Volume 12 | Issue 2 | Features | 236 | Copyright © February 2013
Pipeline Previews brings to you information on the newest drugs and medical products as they become available to the dermatologic community. This department may include additional information from th...
Read MoreProgressive Multifocal Leukoencephalopathy and Reversible Progressive Leukoencephalopathy Syndrome in Dermatologic Therapy
February 2013 | Volume 12 | Issue 2 | Original Article | 20 | Copyright © February 2013
Progressive multifocal leukoencephalopathy (PML) is a frequently fatal demyelinating disease of the brain caused by activation of the John Cunningham virus. It typically occurs in immunocompromised pa...
Read MoreEfficacy and Safety of Ustekinumab in Chinese Patients With Moderate to Severe Plaque-type Psoriasis: Results From a Phase 3 Clinical Trial (LOTUS)
February 2013 | Volume 12 | Issue 2 | Original Article | 166 | Copyright © February 2013
Background: Available biologic agents for the treatment of psoriasis in China are limited.
Objectives: The LOTUS study is a phase 3, double-blind, placebo-controlled study that eva...
Read MoreCalcipotriene Plus Betamethasone Dipropionate Topical Suspension for the Treatment of Mild to Moderate Psoriasis Vulgaris on the Body: A Randomized, Double-Blind, Vehicle-Controlled Trial
January 2013 | Volume 12 | Issue 1 | Original Article | 92 | Copyright © January 2013
Background/Objectives: A combination topical suspension/gel containing calcipotriene plus betamethasone dipropionate has been developed as a safe and effective treatment for patients with psori...
Read MoreRecommendations for the Best Possible Use of Botulinum Neurotoxin Type A (Speywood Units) for Aesthetic Applications
January 2013 | Volume 12 | Issue 1 | Original Article | 80 | Copyright © January 2013
The botulinum neurotoxin (BoNT) product Azzalure (manufactured by Ipsen Biopharm Limited, Wrexham, UK; distributed by Galderma), measured in Speywood units (s.U) has been available since 2009 for temp...
Read MoreResident Rounds. Part III: Multicentric Reticulohistiocytosis Presenting as Granuloma Annulare
December 2012 | Volume 11 | Issue 12 | Features | 1509 | Copyright © December 2012
Clearance of Nasal Staphylococcus aureus Colonization With Triple Antibiotic Ointment
December 2012 | Volume 11 | Issue 12 | Original Article | 1490 | Copyright © December 2012
Background: The prevalence of Staphylococcus aureus colonization of healthcare workers is reported at 30%, with colonization rates for methicillin-resistant S aureusRead More
Improvement in Signs and Symptoms of Plaque Psoriasis After 1 Week of Treatment With Clobetasol Propionate 0.05% Spray
December 2012 | Volume 11 | Issue 12 | Original Article | 1455 | Copyright © December 2012
Clobetasol propionate 0.05% spray (CPS) is a topical, super-high-potent corticosteroid indicated for the treatment of moderate to severe plaque psoriasis. Two pivotal trials of CPS investigated the e...
Read MoreTreatment of Severe Psoriasis With Ustekinumab During Pregnancy
October 2012 | Volume 11 | Issue 10 | Case Reports | 1240 | Copyright © October 2012
We present the case of a female, aged 22 years, with a long history of recalcitrant pustular psoriasis and psoriatic arthritis, treated with ustekinumab during pregnancy. The result of treatment was a...
Read MorePSOLAR: Design, Utility, and Preliminary Results of a Prospective, International, Disease-Based Registry of Patients With Psoriasis Who are Receiving, or are Candidates for, Conventional Systemic Treatments or Biologic Agents
October 2012 | Volume 11 | Issue 10 | Original Article | 1210 | Copyright © October 2012
Background: Long-term observational studies can better characterize the impact of systemic agents on psoriasis.
Objective: To describe the on-going Psoriasis Longitudinal Assessmen...
Read MoreIs it Time to Re-evaluate the Treatment of Pemphigus?
October 2012 | Volume 11 | Issue 10 | Original Article | 1200 | Copyright © October 2012
Pemphigus vulgaris, foliaceous, and vegetans are potentially fatal, autoimmune, vesiculobullous mucocutaneous diseases. In order to prevent potentially fatal infection and other complications, most pa...
Read MoreManagement of Severe Atopic Dermatitis in Children
October 2012 | Volume 11 | Issue 10 | Original Article | 1158 | Copyright © October 2012
Severe childhood atopic dermatitis refers to the presence of recurrent, widespread, eczematous dermatitis that significantly interferes with the daily activities and/or the quality of life of the affe...
Read MoreSafety of Dermal Fillers
September 2012 | Volume 11 | Issue 9 | Original Article | 1053 | Copyright © September 2012
Facial wrinkles are the most visible morphological change of the aging process. Therefore, several rejuvenation methods have been developed to cure these unloved signs of the times, such as botulinum ...
Read MoreUstekinumab for Treatment of Plaque Psoriasis in a Patient With Down Syndrome
August 2012 | Volume 11 | Issue 8 | Case Reports | 1000 | Copyright © August 2012
Down syndrome (DS) is the most common chromosomal disorder and a major cause of mental retardation. Down syndrome phenotype is complex and may present a combination of dysmorphic features, congenital ...
Read MoreThe Use of Cyclosporine in Dermatology
August 2012 | Volume 11 | Issue 8 | Original Article | 979 | Copyright © August 2012
Cyclosporine is an immunosuppressive drug that acts selectively on T-cells by inhibiting calcineurin phosphorylase. It has been used in dermatology since its approval for US Food and Drug Administrati...
Read MoreTrends in Older Adult Psoriasis Outpatient Health Care Practices in the United States
August 2012 | Volume 11 | Issue 8 | Original Article | 957 | Copyright © August 2012
Background: Psoriasis is among the top dermatologic diagnoses for older adult patients, and the number of older adult psoriasis patients is expected to rise.
Purpose: To characteri...
Read MoreOpen Label Study to Evaluate the Efficacy of Re-Treatment With Etanercept in Patients With Psoriasis
August 2012 | Volume 11 | Issue 8 | Original Article | 950 | Copyright © August 2012
Background: Etanercept has been used to treat chronic plaque psoriasis. Previously reported data demonstrated that some patients experienced secondary failure and frequently rotational-switch t...
Read MoreUstekinumab Improves Health-Related Quality of Life in Korean and Taiwanese Patients With Moderate to Severe Psoriasis: Results from the PEARL Trial
August 2012 | Volume 11 | Issue 8 | Original Article | 943 | Copyright © August 2012
Background: The PEARL study showed that the proportion of psoriasis patients achieving the primary endpoint (at least 75% improvement from baseline to week 12 in the Psoriasis Area and Severity...
Read MoreA Randomized Controlled Study of Combination Therapy With Alefacept and Narrow Band UVB Phototherapy (UVB) for Moderate to Severe Psoriasis: Efficacy, Onset, and Duration of Response
August 2012 | Volume 11 | Issue 8 | Original Article | 929 | Copyright © August 2012
Background: Alefacept is an effective intermittent treatment for psoriasis that can provide long-lasting remissions. Combination therapy with narrow-band ultraviolet B (nbUVB) phototherapy may ...
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