Case-based Considerations in the Treatment of Actinic Keratoses: Utilizing Combination or Sequential Therapy With 5-fluorouracil Cream and Destructive Treatments

July 2010 | Volume 9 | Issue 7 | Case Report | 864 | Copyright © 2010

Anne Han MD, Carolin Penrose MD, Arathi Goldsmith DO, Ellen S. Marmur MD


Dermatologic conditions associated with prolonged sun exposure represent a substantial portion of visits to the dermatologist’s office, particularly among elderly populations. Actinic keratoses are premalignant lesions that increase in frequency with each decade of life and have the potential to progress to squamous cell carcinoma. Non-melanoma skin cancers, such as squamous cell carcinoma and basal cell carcinoma, also represent sun-related conditions that require early and aggressive treatment. Therapeutic options for these conditions are abundant and range from topical field-directed therapies to destructive, lesion-directed procedures. Choice of therapy depends on the types and extent of lesions with which a patient presents; often, a combination of treatments provides the optimal means for successful outcomes. The following case-based review represents typical situations where multiple treatments were combined to manage actinic keratosis, squamous cell carcinoma and basal cell carcinoma in patients over an extended treatment period.

Purchase Original Article

Purchase a single fully formatted PDF of the original manuscript as it was published in the JDD.

Download the original manuscript as it was published in the JDD.

Contact a member of the JDD Sales Team to request a quote or purchase bulk reprints, e-prints or international translation requests.

To get access to JDD's full-text articles and archives, upgrade here.

Save an unformatted copy of this article for on-screen viewing.

Print the full-text of article as it appears on the JDD site.

→ proceed | ↑ close

Related Articles