Is Topical Dapsone Safe in Glucose-6-phosphate Dehydrogenase-deficient andSulfonamide-allergic Patients?

May 2010 | Volume 9 | Issue 5 | Original Article | 532 | Copyright © 2010

Guy F. Webster MD PhD


Topical dapsone gel 5% is indicated for the treatment of acne vulgaris and has been marketed since late 2008. The topical formulation retains the anti-inflammatory benefits of dapsone while minimizing the risk of toxicity associated with systemic exposure. This review summarizes the pharmacokinetic and safety data of topical dapsone gel 5% in acne patients, including those with glucose- 6-phosphate dehydrogenase (G6PD) deficiency, and provides support for dapsone usage in sulfonamide-allergic patients. Overall, topical dapsone gel has a favorable short- and long-term safety profile and has been shown to have no risk of hemolytic anemia, including in G6PD deficient patients. Although there are some structural similarities between dapsone and sulfonamides, dapsone is not a sulfonamide and cross-reaction with sulfonamides has not been demonstrated.

Purchase Original Article

Purchase a single fully formatted PDF of the original manuscript as it was published in the JDD.

Download the original manuscript as it was published in the JDD.

Contact a member of the JDD Sales Team to request a quote or purchase bulk reprints, e-prints or international translation requests.

To get access to JDD's full-text articles and archives, upgrade here.

Save an unformatted copy of this article for on-screen viewing.

Print the full-text of article as it appears on the JDD site.

→ proceed | ↑ close

Related Articles