Aesthetics

The Therapeutic Use of Antioxidants for Melasma

By August 25, 2020No Comments

Featured Article

Featured Article

With a well demonstrated impact on quality of life, melasma is a common cause for seeking dermatologic care. There is no universally efficacious therapy, so combination treatment is preferred. Therapies include topical hypopigmenting agents, laser treatment, microneedling, chemical peels, radiofrequency, and oral medications.1 Furthermore, it is critical for patients to avoid exacerbating factors.

Read more

In this review, authors discuss the well-defined role of oxidative stress in melasma and the therapeutic efficacy of various antioxidants for patients suffering from melasma, focusing on studies investigating the role of vitamin C, azelaic acid, cysteamine, glutathione, carotenoids, and numerous other antioxidants in disorders of hyperpigmentation.

Kayla M. Babbush BS, Remy A. Babbush BS, Amor Khachemoune MD FAAD FACMS

 

Melasma is a chronic and acquired skin disorder of hyperpigmentation that presents with symmetric hypermelanosis of sun exposed areas, especially the face. Disease prevalence, ranging from 1 to 50%, varies with gender, ethnicity, skin phenotype, and sun exposure.

The pathogenesis of melasma is incompletely understood, which poses a challenge for disease management. Causative factors include genetics, ultraviolet (UV) radiation, cosmetics, pregnancy, hormonal therapy, phototoxic drugs, and various medications.

Melasma is evaluated by Melasma Area and Severity Index (MASI) score, modified MASI (mMASI) score, Melasma Quality of Life Scale (MelasQoL), colorimetry, and mexametry.

With a well demonstrated impact on quality of life, melasma is a common cause for seeking dermatologic care. There is no universally efficacious therapy, so combination treatment is preferred. Therapies include topical hypopigmenting agents, laser treatment, microneedling, chemical peels, radiofrequency, and oral medications.1 Furthermore, it is critical for patients to avoid exacerbating factors.

The skin, a protective organ critical in homeostasis, is the site of numerous biochemical processes, including the generation of free radicals, namely reactive oxygen and nitrogen species. Reactive oxygen species (ROS) are necessary for biological signaling processes, but, in excess, ROS can damage biomolecules.3 There is clear evidence of oxidative stress in melasma.

Read Full Article Now
Article Cited in this Post

You May Also Like

Acne Vulgaris Treatment Falls Short

Acne Vulgaris Treatment Falls Short

| Featured Articles, Home page feature, The Latest | No Comments
The majority of acne patients are not likely to achieve success according to FDA guidance. Is the FDA guidance too rigorous? Luciana Nofal What is the likelihood of treatment success…

SANOVAWORKS TO MATCH CMMP GRANTS FOR MEDICAL STUDENTS

| Derm Community, Featured Articles, JDD Highlights | No Comments
SanovaWorks has developed a partnership with and in support of Comprehensive Medical Mentoring Program. We are happy to announce that SanovaWorks will match the CMMP Medical Student Grant fund, which was…
Dyshidrotic eczema picture on the sole of the foot

New Treatment for Dyshidrotic Eczema

| Featured Articles, JDD Highlights | No Comments
Struggling with how to treat dyshidrotic eczema of the hands, palms, fingers or feet? We explore the use of a new medication in the treatment of dyshidrotic eczema and common…

Leave a Reply