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Photodistributed Hyperpigmentation Associated With COVID-19 Vaccination

Rebecca Gibons BS^a, Tanner Harding MD^b, Erica Ginsburg MD^b, Jessica Houpe MD^b, Austinn Miller MD^b, Imara Scott MD^b, Michael Bernhardt MD^b

Although drugs are a common cause of hyperpigmentation, the pathogenesis is unclear and varies based on the offending agent. Classic medications associated with hyperpigmentation secondary to increased melanin deposition include tetracyclines, prostaglandins, nicotine, and antimalarial medications. We report the case of a 70-year-old female who developed photodistributed hyperpigmentation due to increased melanin deposition following COVID-19 vaccination.

Eruptive Lentiginosis Within Resolved Psoriasis Plaques: A Case Report and Systematic Review of the Literature

Andrew Kosharek MD^a, Santanna Patterson MS^a, Di Yan MD^a

Many patients with psoriasis suffer from post-inflammatory pigmentary alteration (PIPA), which remains an unmet treatment need. Eruptive lentiginosis (EL) is a rare form of PIPA where multiple dark brown macules arise within a resolving psoriatic plaque. We present a case of a 68-year-old male with a history of chronic plaque psoriasis and prothrombin deficiency, who developed extensive EL following ixekizumab treatment. In addition, this article will discuss the current literature on risk factors, clinical outcomes, and treatments for EL.