Issue Archive
December 2012 | Volume 11 | Issue 12
Editorials
Original Articles
The Paradigm Shift in Treating Actinic Keratosis: A Comprehensive Strategy
Actinic keratoses (AKs) are cutaneous areas of atypical squamous transformation that are considered to be an early step in the continuum of transformation from normal skin to invasive and metastatic c...
Read MoreSingle-Center, Open-Label Study of a Proprietary Topical 0.5% Salicylic Acid-Based Treatment Regimen Containing Sandalwood Oil in Adolescents and Adults With Mild to Moderate Acne
Background: A proprietary topical blend of salicylic acid and highly puri!ed sandalwood oil from Australia was used in this open-label study in adolescents and adults with mild to moderate facial acn...
Read MoreClindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for Rosacea: Summary of a Placebo-Controlled, Double-Blind Trial
Rosacea is a common, chronic, and poorly understood dermatological condition characterized by an inflammatory component composed of papules and pustules and a vascular component composed of flushing ...
Read MoreThe Efficacy and Tolerability of Dapsone 5% Gel in Female vs Male PatientsWith Facial Acne Vulgaris: Gender as a Clinically Relevant Outcome Variable
Background: Gender differences in skin and acne have been reported.
Objective: To evaluate the effect of gender on the efficacy and tolerability of dapsone 5% gel.
Methods: This was a pool...
Read MoreA Double-Blind, Randomized, Bilateral Comparison of Skin Irritancy Following Application of the Combination Acne Products Clindamycin/Tretinoin and Benzoyl Peroxide/Adapalene
Background: The use of topical medications for acne vulgaris is often limited by their irritant properties. Newer combination preparations are available and offer convenience, but irritant potential m...
Read MoreInflammatory Acne Management With a Novel Prescription Dietary Supplement
Background: Inflammatory acne, particularly in postadolescent women, is increasing in incidence. The most effective therapeutic modality for treatment of this type of acne has been the administration...
Read MoreIn Vivo Antibacterial Effects of Tretinoin-Clindamycin and Clindamycin Aloneon Propionibacterium acnes With Varying Clindamycin Minimum InhibitoryConcentration Levels
Objective: To quantify the antimicrobial effect of clindamycin phosphate 1.2% and tretinoin 0.025% gel and 1% clindamycin phosphate gel in patients with Propionibacterium acnes of varying sensitivity...
Read MoreGender as a Clinically Relevant Outcome Variable in Acne: Benefits of a FixedCombination Clindamycin Phosphate (1.2%) and Benzoyl Peroxide (2.5%)Aqueous Gel
Objective: There is an increasing interest in gender differences both in the pathogenesis and treatment of skin diseases. We investigate whether there were any treatment differences in male and femal...
Read MoreA High-Potency, Multimechanism Skin Care Regimen Provides SignificantAntiaging Effects: Results From a Double-Blind, Vehicle-Controlled Clinical Trial
Skin aging is a multifaceted biological process characterized by the appearance of wrinkles, pigmentation irregularities, and loss of firmness. These symptoms cannot be fully addressed by any single...
Read MoreImprovement in Signs and Symptoms of Plaque Psoriasis After 1 Week of Treatment With Clobetasol Propionate 0.05% Spray
Clobetasol propionate 0.05% spray (CPS) is a topical, super-high-potent corticosteroid indicated for the treatment of moderate to severe plaque psoriasis. Two pivotal trials of CPS investigated the e...
Read MoreNitrosoglutathione Generating Nitric Oxide Nanoparticles as an ImprovedStrategy for Combating Pseudomonas aeruginosa - Infected Wounds
Pseudomonas aeruginosa is a community-acquired, nosocomial pathogen that is an important cause of human morbidity and mortality; it is intrinsically resistant to several antibiotics and is capable of...
Read MoreClinical Efficacy and Safety of a Multimodality Skin Brightener CompositionCompared With 4% Hydroquinone
There are numerous common skin disorders involving hyperpigmentation, including solar lentigines, postinflammatory hyperpigmentation, melasma, freckles, and dyschromia from photoaging. While these co...
Read MoreA Multicenter, Randomized, Vehicle-Controlled Phase 2 Study of Blue Light Photodynamic Therapy With Aminolevulinic Acid HCl 20% Topical Solution for the Treatment of Actinic Keratoses on the Upper Extremities: The Effect of Occlusion During the Drug Incubation Period
Background: Photodynamic therapy (PDT) with aminolevulinic acid (ALA) has been shown to be safe and effective in the treatment of actinic keratoses (AKs) of the face and scalp. A recent small study h...
Read MoreClearance of Nasal Staphylococcus aureus Colonization With Triple Antibiotic Ointment
Background: The prevalence of Staphylococcus aureus colonization of healthcare workers is reported at 30%, with colonization rates for methicillin-resistant S aureus (MRSA) reported between 2.0% and ...
Read MoreA New Treatment Regimen for Rosacea: OnabotulinumtoxinA
Rosacea is a cutaneous condition with several clinical subtypes that are commonly seen in daily medical practice. There are many different treatment modalities for each of the physical findings associ...
Read MoreComparison of Two Techniques Using Hyaluronic Acid to Correct the Tear Trough Deformity
Background: Hyaluronic acid (HA) can be used to correct volume loss associated with periorbital aging.
Objective: To report and compare the efficacy and safety of HA used to treat tear trough de...
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Features
Resident Rounds. Part I: St. Joseph Mercy Health System DermatologyResidency Program
Resident Rounds is a section of the JDD dedicated to highlighting various dermatology departments with residency training programs. Resident Rounds includes three sections: (1) a program spotlight, hi...
Read MoreResident Rounds. Part II: Dermatologic Syndromes and Their Histologic Characteristics
Resident Rounds. Part III: Multicentric Reticulohistiocytosis Presenting as Granuloma Annulare
News, Views, & Reviews
Pipeline Previews
Pipeline Previews brings to you information on the newest drugs and medical products as they become available to the dermatologic community. This department may include additional information from the...
Read MoreClinical Trial Review
Clinical Trial Review is a JDD department designed to provide physicians with information on drugs and devices undergoing clinical testing. It is our goal to inform the reader of the status of select...
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Case Reports
A Challenging Eruption
Eruptions from drugs are among the most frequently reported adverse events. The most frequent etiologic agents include antibiotics and nonsteroidal anti-inflammatory agents. These eruptions are also ...
Read MoreTwo Cases of Hepatitis B in Patients With Moderate to Severe Psoriasis With Ustekinumab
Background: Patients with psoriasis who are treated with systemic and biologic therapies may have an increased risk of infections, including hepatitis B virus (HBV). Cytokines that modulate CD4+ T ce...
Read MoreSuccessful Treatment of Patients Previously Labeled as Having Delusions of Parasitosis With Antidepressant Therapy
Delusions of parasitosis (DOP) is a somatic subtype of delusional disorder, also known as monosymptomatic hypochondriacal psychosis. The management of DOP has been discussed extensively in the medica...
Read MoreFinasteride and Fertility: Case Report and Review of the Literature
Although millions of men have taken or are taking finasteride, there are no documented cases of successful pregnancy in the literature after discontinuation of the drug. Early studies did not show sig...
Read MoreAcanthosis Nigricans Resulting From Repetitive Same-Site InsulinInjections
Although acanthosis nigricans (AN) may be associated with internal malignancies, a benign form is more common, and a subset of these is drug-induced. In this case, a solitary, hyperpigmented, acantho...
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Supplements
Clinical and Economical Considerations in Topical Corticosteroid Selection
Taro Pharmaceuticals Solves a Puzzling Enigma for Dermatologists
FDA regulations require that generic topical steroids match the active ingredients, concentration, and dosage of brand topic...
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