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Lindsay OConnor

Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

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Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various mechanisms of action including direct anti-inflammatory, anti-pruritic, anti-oxidant, anti-fungal, pre-biotic, barrier repair properties, and beneficial effects on skin pH. These have been shown to be of particular benefit in the treatment of atopic dermatitis.

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Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various mechanisms of action including direct anti-inflammatory, anti-pruritic, anti-oxidant, anti-fungal, pre-biotic, barrier repair properties, and beneficial effects on skin pH. These have been shown to be of particular benefit in the treatment of atopic dermatitis.

Blair Allais MD, Adam Friedman MD FAAD

 

 

Oatmeal has a longstanding and rich history pertaining to its dermatologic use. The first documentation of oatmeal for skin health dates back as early as 2000 BC in Arabia and Egypt, where it was described as soothing and protecting in dry or itchy, inflamed skin. Oatmeal flour was subsequently recognized as a topical therapy for a variety of dermatologic conditions in Roman medical literature. The first scientific studies on the skin benefits of oatmeal appeared in the 1930s, including information about the cleansing properties of oatmeal, its role in relieving itch, and its function as a skin protectant.

In the 1940s and 1950s colloidal oatmeal became commercially available both in powder form and mixed with emollient oils, instigating medical studies examining the benefits of colloi-dal oatmeal baths in various xerotic dermatoses.

The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

In 1989, the United States Food and Drug Administration (FDA) approved colloidal oatmeal as a safe and effective over-the-counter drug. In 2003, the FDA noted that colloidal oatmeal could relieve irritation and itching due to a number of dermatoses, providing temporary skin protection.5 Colloidal oatmeal is one of the few products that the FDA recognizes as a safe over the counter treatment. Today it is available in various forms including creams, lotions, shampoos, shaving gels, bath treat-ments, and body wash.

Colloidal oatmeal is the powder obtained from the grinding and processing of whole oat grain. Under strict protocols es-tablished by the US Pharmacopeia, oat grain is ground and processed until no more than 3% of the total particles in the powder exceed 150 μm in size and no more than 20% exceed 75 μm in size.6 The small size of the particles contributes to their ability to deposit on the skin and form an occlusive barrier when dispersed in water. Oat is composed of various types of phytochemicals, which contribute to its wide-ranging function and clinical use. Col-loidal oatmeal consists of sugars and amino acids (65%), proteins (15–20%), lipids (11%), and fiber (5%).7 The most important groups of phytochemicals present in oats include phenolics, β-glucans, lignans, avenanthramides, carotenoids, vitamin E, and phytosterols.

Of the phenolics present in oats, ferulic acid and caffeic acid are strong antioxidants, and fe-rulic acid also has UV absorbing properties.8 Flavonoids, a group of phenolic compounds present in oat, also are capable of absorbing ultraviolet A light from 320–370 nm. β-glucans are polysaccharides of D-glucose monomers and have a high viscosity largely due to their β-(1–3)-linkages.This viscosity contributes to the water-binding properties of oat. Oats also contain a wide range of minerals and vitamins, of which vita-min E is the most clinically relevant. Vitamin E is a naturally occurring antioxidant that protects against oxidative stress, inflammation, and photo-induced aging.

Learn more about the history, basic science, mechanism of Action, and clinical efficacy of colloidal oatmeal in the treatment of Atopic Dermatitis now.

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

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Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

By Featured Articles No Comments

Featured Article

Featured Article

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

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Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

 

 In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging. However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject.

Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin. Collagen is the most abundant component of the extracellular matrix constituting 75% of skin’s dry weight.5 Qualitative and quantitative decline in collagen is associated with cutaneous aging.6 Collagen protein is a right-handed triple helix of parallel polypeptides where every third amino acid residue is glycine (Gly) resulting in X-Y-Gly triplets, where X andY are frequently proline (Pro) and 4-hydroxyproline (Hyp; an amino acid sub- unit unique to collagen), respectively,7 making Pro-Hyp-Gly the most common amino acid triplet unit found in collagen

Native, animal collagen can be extracted from connective tissue in various forms.10 When denatured by heat, collagen forms gelatin, which has been used for centuries as a food source and traditional medicine in Europe and China.

Further enzymatic hydrolysis of gelatin produces collagen hydrolysates (CH) composed of peptides of varying lengths. CH has a lower molecular weight than gelatin, higher water-solubility, and no gelation properties at ambient temperatures, allowing CH to be conveniently formulated into liquid drinks and jelly sticks for oral consumption. In the past decade, CHs have gained popularity as a nutraceutical supplement.

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

Treating the AD Patient During COVID-19

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JDD Multimedia

JDD Podcast

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Treating the AD Patient During COVID-19

Dr. Peter Lio and Dr. Adam Friedman

 

Atopic dermatitis is a relentless, recurring, unreasonable, often recalcitrant inflammatory skin disease that impacts millions of children and adults in the United States alone and requires a tailored treatment plan and ongoing follow up. Now add a global pandemic to the mix – awesome.

Join podcast host Dr Adam Friedman and atopic dermatitis antagonist Dr. Peter Lio as they discuss practical approaches to managing atopic dermatitis in the era of COVID-19. Telemedicine, topicals, and tons of systemic talk!

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This podcast is supported by an independent medical education grant provided by Sanofi Genzyme Regeneron.

 

Learning Objectives:
Upon completion of this podcast, learners should be able to:
  • Formulate AD treatment plans that may decrease susceptibility and spread of viral infections, including COVID-19
  • Identify new and emerging therapeutic considerations for managing atopic dermatitis during the current COVID-19 pandemic

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Treating the AD Patient During COVID-19

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iTunes Google Play Stitcher TuneIn Dr. Peter Lio and Dr. Adam Friedman   Atopic dermatitis is a relentless, recurring, unreasonable, often recalcitrant inflammatory skin disease that impacts millions of children…

Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

| Podcast Highlights, Skin Cancer | No Comments
iTunes Google Play Stitcher TuneIn Drs. Sherry Pagoto and Adam Friedman   Why is is that we tend to do things we know are bad for us? Candy, alcohol, Tinder...the…

NEW from the JDD Podcast: “The Science of Sun Protection”

| Photoprotection, Podcast Highlights, Skin Cancer | No Comments
iTunes Google Play Stitcher TuneIn Dr. Neal Bhatia and Dr. Adam Friedman   Photoprotection works, plain and simple. Yet all too often we must defend good science, dispel unfounded myths,…

NEW Webinar – What’s New in Acne Management: What We Have Learned from Increased Understanding of Acne Pathophysiology

By JDD Webinars No Comments

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Featured Webinar

Join Leon H. Kircik, MD; Linda Stein Gold, MD;  and Jonathan S. Weiss, MD as they discuss the medical interventions that target one or more of the key factors contributing to the development of acne lesions.

  • November 10th, 2020
  • 7:00 PM – 8:00 PM EST
Register Now!

Join Leon H. Kircik, MD; Linda Stein Gold, MD;  and Jonathan S. Weiss, MD as they discuss the medical interventions that target one or more of the key factors contributing to the development of acne lesions.

Acne pathogenesis is multifactorial and not clearly understood; a key factor includes genetics and may result as in interplay of release of inflammatory mediators into the skin, follicular hyperkeratinization with subsequent plugging of the follicle, Cutibacterium acne (C. acnes), formerly Propionibacterium acnes or P. acnes, follicular colonization and excess sebum production.

C. acnes has been shown to mediate inflammatory processes at the site of the sebaceous follicle contributing to the formation of free radical species and generating pro-inflammatory cytokines. Excess sebum production and
C. acnes colonization lead to the formation of microcomedones leading to the development of open or closed comedones, inflammatory papules, pustules and cysts characteristic of acne.
Acne severity and grade (comedonal, papulopustular, mixed, nodular), skin type, presence of acne scarring and postinflammatory hyperpigmentation, menstrual cycle history (in women), skin current skin care regimen are
factors influencing treatment with classes of topical agents include: comedolytic (anticomedogenic), antimicrobial, antibiotic and antiinflammatory; each impact on the four main pathogenic features of acne.
Join Drs. Leon H. Kircik, Linda Stein Gold, and Jonathan S. Weiss as they discuss the medical interventions generally targeting one or more of the key factors contributing to the development of acne lesions: follicular hyperproliferation and abnormal desquamation (topical and oral retinoids, azelaic acid, salicylic acid, hormonal therapy), increase sebum production (oral isotretinoin, hormonal therapy), C. acnes proliferation (benzoyl peroxide, topical and oral antibiotics, azelaic acid) and inflammation (oral isotretinoin, oral tetracyclines, topical retinoids, azelaic acid).
Register Now!

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

Revisiting Handwashing – As It Is Absolutely Essential

By Featured Articles, Global Health, The Latest No Comments

Featured Article

Featured Article

As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without a readily available, effective COVID-19 vaccine, and as the numbers of infected individuals continues to climb, the best practices to ensure public safety are rooted in good personal hygiene and prevention of transmission of the novel coronavirus SARS-CoV-2. To that end, in addition to properly wearing adequate facial covering, individuals should properly wash their hands to prevent direct auto-inoculation.

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As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without a readily available, effective COVID-19 vaccine, and as the numbers of infected individuals continues to climb, the best practices to ensure public safety are rooted in good personal hygiene and prevention of transmission of the novel coronavirus SARS-CoV-2.

Graham L. Litchman DO MS, Justin W. Marson MD, Neal Bhatia MD, Brian Berman MD PhD

 

Despite being a technique widely taught from primary school-age, many individuals do not practice adequate hand hygiene and, even pre-pandemic, suffered from economic losses of missed days at work and/or school.1 Study data have shown that the simple act of handwashing, regardless of other medical interventions, can reduce the transmission of respiratory viruses.2 Furthermore, handwashing with an adequate antimicrobial product for at least 20 seconds can reduce the risk of transmission of viruses, including respiratory viruses like SARS-CoV-2.

Consistent use of water and soap or alcohol-based sanitizer has been estimated by the World Health Organization (WHO) to reduce pathogen spread up to 50% among healthcare workers. Newer studies are now focusing on “virucidal” properties of alternative and novel agents and combinations.

The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

Sodium hypochlorite (chemically known as NaOCl and more commonly referred to as “Liquid Bleach”), is a chlorine-derived product, that has been used as a disinfectant for over 200 years, and came to prominence in the 1930s. Open wounds were treated with hypochlorite solutions during World War I, which lead to more routine use within hospitals.6 This paired with aggressive marketing, ultimately lead to “Clorox” becoming the household name for a disinfectant.

The antimicrobial effects of these chlorine-derived products comes from their ability to disrupt the membranes of bacteria, fungi, and viruses as well as induce oxidative damage to the necessary proteins and enzymes for microbial survival.7 The strengths of chlorine-derived agents are determined by their concentration and the solvent (typically water) in which they are mixed. When NaOCl is added to water the reaction yields hypochlorous acid ion (HOCl) and sodium hydroxide (NaOH).

Because NaOCl is more stable, it usually predominates at equilibrium. However, in more acidic solvents, the concentration of HOCl increases. This increases the potency of the solution’s antimicrobial properties given that HOCl is 80–120 times more efficient at eliminating bacteria, viruses, and fungi than sodium hypochlorite. Hypochlorous acid on its own is far too caustic and is not appropriate for application to the skin or human body; consequently, it is reserved for disinfecting inanimate objects, demonstrating that its strength comes at a price.

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

View the Latest Discoveries in Atopic Dermatitis, Anti-Aging, and Medical Dermatology

By Featured Articles, JDD Highlights No Comments

Dermatology News

JDD Highlights

The October issue of the Journal of Drugs in Dermatology is available now. This month, we focus on atopic dermatitis with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Read the October JDD Now

Atopic Dermatitis, Public Health, Anti-Aging, and Medical Dermatology

The October issue of the Journal of Drugs in Dermatology is available now. This month, we focus on atopic dermatitis, with special features on Public Health, Anti-aging, Aesthetic, and Medical Dermatology.

Article Highlights

 

Editor's Picks

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Treating the AD Patient During COVID-19

| Podcast Highlights | No Comments
iTunes Google Play Stitcher TuneIn Dr. Peter Lio and Dr. Adam Friedman   Atopic dermatitis is a relentless, recurring, unreasonable, often recalcitrant inflammatory skin disease that impacts millions of children…

NEW Webinar – Differentiating Approach to Acne Therapy: Women Vs. Men

By JDD Webinars No Comments

Featured Article

Featured Webinar

Join Leon H. Kircik, MD and Julie Harper, MD as they discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris.

  • October 27th, 2020
  • 7:00 PM – 8:00 PM EST
Register Now!

Join Drs. Leon H. Kircik, MD and Julie Harper, MD as they discuss Acne severity and grade (comedonal, papulopustular, mixed, nodular), skin type, presence of acne scarring and postinflammatory hyperpigmentation, menstrual cycle history (in women), and more, as well as the factors influencing treatment with classes of topical agents.

Acne vulgaris is a chronic inflammatory dermatologic disease affecting an estimated 80% of the population at some point in their life; 85% of adolescents and young adult s may experience acne and prevalent in adults with more adult women being afflicted than adult men, raising the possibility that gender difference in skin may influence the pathogenesis of acne and
treatment response.
Dermatologists indicate late-onset or adult -onset acne is becoming increasingly common in women in their 20s to 50s and research shows a large number of women over age 25 have acne and the prevalence of acne remains constant until age 44 at which time there is a decrease in incidence.
Join Drs. Leon H. Kircik, MD and Julie Harper, MD as they discuss Acne severity and grade (comedonal, papulopustular, mixed, nodular), skin type, presence of acne scarring and postinflammatory hyperpigmentation, menstrual cycle history (in women), and more, as well as the factors influencing treatment with classes of topical agents.
Register Now!

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

By Podcast Highlights, Skin Cancer No Comments

JDD Multimedia

JDD Podcast

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How to Listen

Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

Drs. Sherry Pagoto and Adam Friedman

 

Why is is that we tend to do things we know are bad for us? Candy, alcohol, Tinder…the list goes on. What about not following practices that have a library of evidence supporting their use, like sunscreen and photo-protection?

To better understand this conundrum JDD Podcast host Dr. Adam Friedman recruited mental health guru Dr. Sherry Pagoto, Professor in the Department of Allied Health Sciences at the University of Connecticut and Director of the UConn Center for mHealth and Social Media, to dive deep into human behavior and how this relates to medical compliance.
Find a couch to lie down on as you digest the litany of psychosocial pearls Dr. Pagoto shares, rounded out by some evidenced based guidance on using social media to engage a broader audience. #dontmissthispodcast
This podcast was supported by Johnson & Johnson Consumer Inc.
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CME Available
This enduring continuing education activity is supported by an independent medical education grant provided by Johnson & Johnson Consumer Inc. Participants who earn a minimum, passing grade of 70% would be eligible to receive up to 0.5 credit hours AMA PRA Category 1™ and ANCC credit per podcast. A total of 1 hour for this two-part Sun Protection series.

Learning Objectives

 

Upon completion of this enduring, internet-based series of continuing education activities,  participants should be able to:
  • Develop strategies leading to effective clinician-patient dialogues to better motivate patients to integrate regular use of sunscreens in their skin care regimen
Take CME Now

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Treating the AD Patient During COVID-19

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iTunes Google Play Stitcher TuneIn Dr. Peter Lio and Dr. Adam Friedman   Atopic dermatitis is a relentless, recurring, unreasonable, often recalcitrant inflammatory skin disease that impacts millions of children…

Understanding and Changing Patient Behavior and Minimizing Risk of UV Damage

| Podcast Highlights, Skin Cancer | No Comments
iTunes Google Play Stitcher TuneIn Drs. Sherry Pagoto and Adam Friedman   Why is is that we tend to do things we know are bad for us? Candy, alcohol, Tinder...the…

NEW from the JDD Podcast: “The Science of Sun Protection”

| Photoprotection, Podcast Highlights, Skin Cancer | No Comments
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Premiere Webinar Event: Recognizing the Role of The Sebaceous Gland in Acne

By JDD Webinars No Comments

Featured Article

Featured Webinar

Join Leon H. Kircik, MD and James Q. Del Rosso, DO, FAOCD, FAAD as they discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris.

Register Now!

Join Leon H. Kircik, MD and James Q. Del Rosso, DO, FAOCD, FAAD as they discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris.

Androgen and androgen receptor (AR) may play important roles in several skin related diseases including androgenetic alopecia and acne vulgaris and recent studies suggest AR and androgens play distinct roles in the skin pathogenesis, and AR seems to be a better target than androgens for the treatment of these skin diseases.

Tune in as Leon H. Kircik, MD and James Q. Del Rosso, DO, FAOCD, FAAD discuss the mechanisms by which androgen/AR regulate sebocyte activity in acne vulgaris, and how suppressing AR function by treating with antiandrogens alone, or in combination with antibiotics (i.e., to reduce bacterial infection) might be a potential therapeutic approach to treat acne more effectively.

The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

Register Now!

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

What are the Skincare Benefits of Niacinamide?

By Aesthetics, Featured Articles No Comments

Featured Article

Featured Article

A 2016 study from Journal of Drugs in Dermatology suggests that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

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A 2016 study from Journal of Drugs in Dermatology (“Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol“), which was recently cited in an article on Prevention.com, suggests that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection. 

Patricia Farris MD, Joshua Zeichner MD, and Diane Berson MD

 

Consumers are increasingly interested in over-the-counter skin care products that can improve the appearance of photodamaged and aging skin. This 10-week, open-label, single- center study enrolled 25 subjects with mild to moderate hyperpigmentation and other clinical stigmata of cutaneous aging including fine lines, sallowness, lack of clarity, and wrinkling. Their mean age was 53.4±7.7 years. The test product contained retinol 0.5% in combination with niacinamide 4.4%, resveratrol 1%, and hexylresorcinol 1.1% in a moisturizing base. Subjects were provided a skin care regimen including a cleanser, hydrating serum, moisturizer, and an SPF 30 sunscreen for daily use. The test product was applied only at night.

The use of this skin brightening/anti-aging cosmeceutical was found to provide statistically significant improvements in all efficacy endpoints by study end. Fine lines, radiance, and smoothness were significantly improved as early as week 2 (P<.001). By week 4, hyperpigmentation, overall skin clarity, evenness of skin tone, and wrinkles showed statistically significant improvement compared to baseline. Mild retinoid dermatitis including flaking and redness occurred early in the study as reflected by tolerability scores. By week 10, subjects reported no stinging, itching, dryness, or tingling.

The results of this open-label clinical study suggest that a topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol is efficacious and tolerable for skin brightening/anti-aging when used with a complementary skin care regimen including SPF 30 sun protection.

Read Full Article Now
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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

| Atopic Dermatitis, Featured Articles, The Latest | No Comments
Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

| Featured Articles | No Comments
Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

| Featured Articles, Global Health, The Latest | No Comments
As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

Biological Effects of Hyaluronic Acid-Based Dermal Fillers and Laser Therapy on Human Skin Models

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Featured Article

This study investigates the molecular effects of different stabilized HA and poly-l-lactic acid (PLLA)-based fillers with and without subsequent additional fractional laser co-treatment.

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This study investigates the molecular effects of different stabilized HA and poly-l-lactic acid (PLLA)-based fillers with and without subsequent additional fractional laser co-treatment.

Laura Huth PhD, Yvonne Marquardt, Ruth Heise PhD, Katharina Fietkau, Jens Malte Baron MD, Sebastian Huth PhD

 

Injection of hyaluronic acid (HA) dermal fillers is one of the most frequently performed aesthetic procedures. HA fillers exist in many different formulations differing in HA concentration, particle size and cross-linking density.

While HA fillers with high-density and large particles are recommended for deep dermal injections, fillers with low-density and small particles are more commonly used for fine lines.

The direct biological effects of dermal fillers monotherapy and combination therapy with ablative fractional CO2- or Er:YAG laser irradiation on human skin cells are not completely understood. Organotypic three-dimensional (3D) skin equivalents have been established for standardized studies of the human skin.

The aim of the present study was to investigate the molecular effects of different stabilized HA and poly-l-lactic acid (PLLA)-based fillers with and without subsequent additional fractional laser co-treatment.

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

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Colloidal oatmeal has a long-standing history in the treatment of dermatologic disease. It is composed of various phytochemicals, which contribute to its wide-ranging function and clinical use. It has various…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

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Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been…

Revisiting Handwashing – As It Is Absolutely Essential

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As the coronavirus pandemic continues into the second half of 2020, states across the US remain steadfast in their search to determine the safest methods of returning to normalcy. Without…

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

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800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin.

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Improvements in skin health is a well-researched benefit of taking collagen – in fact, according to a January 2019 Journal of Drugs in Dermatology study, (recently featured in an Every Day Health article, ” 8 Potential Benefits of Collagen – and 1 Thing it Can’t Do”), 800 patients who took up to 10 grams of collagen per day, experienced improvement in skin elasticity, moisture retention, and increased density of collagen fibers in the skin.

Franchesca D. Choi BS RPh, Calvin T. Sung BS, Margit L.W. Juhasz MD, Natasha Atanaskova Mesinkovska MD PhD

Nutrition is thought to play an important role in skin homeostasis. The use of nutraceuticals or “functional foods” in skincare along with technological innovations within the food industry has been rising.

In 2016, the collagen market was valued at an estimated 3.71 billion USD and is projected to reach 6.63 billion USD by 2025. Collagen supplements, originating from various sources (eg, porcine, bovine, marine) and available in numerous formulations (eg, protein, gelatin, hydrolysate, peptides), are marketed as improving skin integrity and modulating skin aging.

However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in over-the-counter collagen supplements, as well as minimal peer-reviewed literature on the subject. Fortunately, there are increasing numbers of clinical studies regarding potential effects of collagen-based dietary supplements on skin.

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Colloidal Oatmeal Part I: Clinical Efficacy in the Treatment of Atopic Dermatitis

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