Worsening Injection Site Reactions with Continued Use of Etanercept
March 2003 | Volume 2 | Issue 2 | Case Reports | 184 | Copyright © March 2003
Kimberly R. Edwards, MD; Christen M. Moward, MD and Wiiliam B. Tyler, MD
Abstract
We report the case of a patient with persistent and worsening injection site reactions associated with subcutaneous
etanercept therapy. Injection site reactions are well documented to occur early in therapy; however they
typically decrease in frequency over time. This patient developed early injection site reactions that have persisted
and worsened into his tenth month of treatment with etanercept. 
