Unmet Needs in Psoriasis Patients

August 2022 | Volume 21 | Issue 8 | 839 | Copyright © August 2022


Published online August 1, 2022

doi:10.36849/JDD.6589

Caroline Porter MD, Alexander D. Woods , Madeleine Mendelow , Caitlin Purvis MD, Steven R. Feldman MD PhD

Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC

Abstract
Background: Psoriasis can greatly impact patients' quality of life. The introduction of new treatments has improved treatment outcomes, but treatment gaps may still exist.
Objective: Identify unmet treatment needs in patients with psoriasis.
Methods: Participants aged 18 years or older, with an Amazon Mechanical Turk account, who reported diagnosis of psoriasis and correctly answered an attention check question were included. Results were analyzed using descriptive and inferential statistics.
Results: Of the 417 participants who met study inclusion criteria, 51.1% were female, and 39.3% were 31-40 years of age; 61.2% reported mild, 25.4% moderate, and 13.4% severe psoriasis. Most (74.8%) were currently under treatment; half (51.6%) were mostly or completely satisfied with treatment, while 24.5% were slightly or not at all satisfied. Respondents were most satisfied with topical (59.5%), followed by oral (46%), and injectable treatments (19.9%). Most (78.7%) slightly or strongly felt there should be more cost-effective options. Gaps in current psoriasis treatment options included more affordable topical and oral treatments that work faster and require less frequent use.
Limitations: The use of an English survey and Amazon Mechanical Turk precludes certain populations from this study. Participants were not asked to provide their current form of psoriasis treatment.
Conclusions: Despite advances in psoriasis treatment, there remains a desire for more effective, faster, longer acting, and less costly, more accessible treatments.

J Drugs Dermatol. 2022;21(8):839-844. doi:10.36849/JDD.6589

INTRODUCTION

Psoriasis is a chronic, relapsing, and remitting inflammatory skin disease affecting 7.4 million adults in the United States (US).1 Psoriasis can have devastating effects on numerous aspects of life.2-4 The financial burden in the US is considerable, it costs an estimated $112 billion per year to treat psoriasis.5-7 Although many treatments exist, the National Psoriasis Foundation (NPF) reports over half of patients in the US are dissatisfied with their psoriasis treatment.6-8

Topical therapies are first-line treatments for mild psoriasis, whereas phototherapy, systemic therapies, or biologic therapies are used to manage moderate to severe psoriasis and residual disease. Topical therapies can be time-consuming, messy, expensive, and requiring different potencies for different body areas. Newer therapies have sought to improve this with the creation of single, fixed combination topicals in different vehicle types that are less messy, more convenient, and cosmetically elegant. Topical drugs with new mechanisms of action are under development.5 Systemic therapies for moderate to severe psoriasis, consisting of 3% or more of the body surface area (BSA), have improved dramatically with the introduction of biologics, making clearing and normalization of quality of life a realistic possibility for many patients.9,10

Despite the introduction of safe and effective novel therapies in treating psoriasis, many people remain untreated or undertreated and unsatisfied, particularly those with moderate or severe psoriasis.6,11,12 To further assess psoriasis treatment needs, we sought to determine what remaining gaps patients with psoriasis perceive.

MATERIALS AND METHODS

Following approval from the Wake Forest University Institutional Review Board (IRB), 1,345 participants were recruited through Amazon Mechanical Turk (MTurk), an online crowdsourcing platform that allows participants to find paid tasks relevant to them. Anyone with internet access can sign-up for an MTurk