Treatment of Confluent and Reticulated Papillomatosis Using Fixed-Dose Clindamycin phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel

May 2026 | Volume 25 | Issue 5 | 9769 | Copyright © May 2026


Published online April 29, 2026

Faraz Yousefian DOa*, Jacob Pattee BSb*, Naiem T. Issa MD PhDc,d,e

aForefront Dermatology, Manitowoc, WI
bUniversity of Incarnate Word, San Antonio, TX
cForefront Dermatology, Vienna, VA
dDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL
eDepartment of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC

*First co-authors

Abstract
Introduction: Confluent and reticulated papillomatosis (CARP) is a rare, non-systemic disease usually treated using oral antibiotics.
Case Presentation: We present a 15-year-old male with CARP for whom initial treatment with doxycycline, ketoconazole shampoo, and topical minocycline was ineffective. He was subsequently treated with a combination of fixed-dose triple-combination clindamycin phosphate 1.2% / adapalene 0.15% / benzoyl peroxide 3.1% (CAB) gel and a sodium hypochlorite-based body wash, resulting in complete clearance after 3 months.
Discussion: CARP is most often treated with oral or topical antibiotics. This case highlights the successful use of topical combination therapy with CAB, which is FDA approved for acne, plus a sodium hypochlorite-based body wash as a safe and effective alternative.
Conclusion: This case supports the potential role of CAB in CARP management and highlights the value of non-systemic options for treatment-resistant cases.

INTRODUCTION

Confluent and reticulated papillomatosis (CARP) is a chronic dermatologic condition characterized by multiple hyperpigmented papules that converge to form plaques or patches and reticulate peripherally. The etiology of CARP remains unclear, but current evidence most strongly supports bacterial association and abnormal keratinization.1 Oral antibiotics are the most frequently used first-line therapy for treating CARP.2 The authors present a case of CARP treated successfully with topical fixed-dose triple-combination clindamycin phosphate 1.2% / adapalene 0.15% / benzoyl peroxide 3.1% (CAB) gel as a novel treatment.

Case Presentation
A 15-year-old Caucasian male presented with an itchy, discolored rash on his epigastric region for the past several months. Physical examination revealed confluent and reticulated brown patches on the epigastric lesions (Figure 1). A punch biopsy was performed with a clinical differential diagnosis that included tinea versicolor and CARP. Histopathology revealed hyperkeratosis, papillomatosis, and mild acanthosis, confirming the diagnosis of CARP. The patient demonstrated refractory