The Role of Hormone Therapy in Female Aesthetic Rejuvenation

September 2022 | Volume 21 | Issue 9 | 954 | Copyright © September 2022


Published online September 1, 2022

doi:10.36849/JDD.6232

Keira Barr MDa, Alana Kurtti BSb-d, Jared Jagdeo MD MSc,d

aResilient Health Institute, Gig Harbor, WA
bRutgers Robert Wood Johnson Medical School, Piscataway, NJ
cDermatology Service, VA New York Harbor Healthcare System, Brooklyn, NY
dDepartment of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY

Abstract
Hormones are intricately involved in age-related aesthetic changes. Declining levels of several hormones in the postmenopausal period are associated with unwanted changes in appearance, including weight gain, fat redistribution, aged skin, and hair thinning. Hormone therapies may prevent or reverse these changes.

In this article, we explore the role of estrogen, progesterone, testosterone, dehydroepiandrosterone, and melatonin in female aesthetics. Based on our current understanding of the literature, dermatologists may safely and efficaciously incorporate several hormone formulations in their repertoire of treatments for female aesthetic rejuvenation.

J Drugs Dermatol. 2022;21(9):954-960. doi:10.36849/JDD.6232

INTRODUCTION

The World Health Organization defines health as a state of complete physical, mental, and social well-being, and not merely the absence of disease or infirmity.1 This holistic definition of health is relevant to aesthetic treatments, which are often inaccurately deemed trivial or superfluous. Physical appearance has direct correlations with social and psychological health, and aesthetic treatments can substantially improve a person’s self-esteem, social functioning, and quality of life, all essential tenets to overall wellness.2,3 Thus, the profound benefits that aesthetic treatments offer should not be overlooked due to their elective nature.

With an aging population, more women than ever are seeking minimally invasive ways to maintain a healthy, youthful aesthetic. According to market research, the global anti-aging industry reached a value of $58.5 billion in 2020 and is expected to reach $88.3 billion by 2026.4 While a variety of anti-aging therapies exist, researchers are continually seeking novel cosmeceuticals. Because age-related declines in hormones, particularly in the postmenopausal period, have significant aesthetic consequences on women, including skin aging, weight gain, and muscle loss, the role hormones play in maintaining a healthy female aesthetic has piqued the interest