Rhabdomyolysis Associated with Quinacrine Therapy in a Patient with Chronic Cutaneous Lupus Erythematosus

March 2005 | Volume 4 | Issue 2 | Case Reports | 225 | Copyright © March 2005

CPT Naomi Creel MC USA, Victoria Werth MD

We describe a patient who developed rhabdomyolysis 6 weeks after starting combination therapy with hydroxychloroquine and quinacrine for the treatment of chronic cutaneous lupus erythematosus (CCLE). Myopathy due to 4-aminoquinolone antimalarials has been well documented. It is plausible that quinacrine may induce muscle injury in a manner similar to other antimalarials but, to our knowledge, rhabdomyolysis associated with antimalarial therapy has not been reported.