INTRODUCTION
Radiofrequency microneedling (RFMN) is a non-invasive skin rejuvenation technique that uses a needle array to deliver radiofrequency radiation to induce thermal injuries to the dermis. The process encourages the generation of new extracellular matrix (ECM) proteins, such as collagen and elastin. It can help diminish the appearance of fine lines, wrinkles, and acne scars. Long-pulsed fractional RFMN, however, entails a lengthy recovery time of a week or longer, accompanied by erythema, edema, and purpura, remaining a serious hindrance for many patients.
Topical therapies have shown benefits in reducing downtime and enhancing the healing process after dermatological procedures.1 The application of a topical solution containing antioxidants, anti-inflammatory drugs, and hyaluronic acid following fractional laser resurfacing significantly shortened the duration of erythema and increased skin hydration.2,3 Similarly, after RFMN, a topical mixture of all-trans-retinol, epidermal growth factor, and hyaluronic acid improved skin texture and overall skin quality.1
Angiopoietin-1 is a glycoprotein that interacts with the ECM, promotes cell survival and wound healing, protects from oxidative damage, and results in stable angiogenesis.4 Angiopoietin-1 also antagonizes actions of angiopoietin-2, which is known to associate with chronic inflammation, destabilization of blood vessels, and aging.5 We therefore hypothesized that developing a recovery regimen based on an angiopoietin-1-derived peptide and a suitable ECM component
Topical therapies have shown benefits in reducing downtime and enhancing the healing process after dermatological procedures.1 The application of a topical solution containing antioxidants, anti-inflammatory drugs, and hyaluronic acid following fractional laser resurfacing significantly shortened the duration of erythema and increased skin hydration.2,3 Similarly, after RFMN, a topical mixture of all-trans-retinol, epidermal growth factor, and hyaluronic acid improved skin texture and overall skin quality.1
Angiopoietin-1 is a glycoprotein that interacts with the ECM, promotes cell survival and wound healing, protects from oxidative damage, and results in stable angiogenesis.4 Angiopoietin-1 also antagonizes actions of angiopoietin-2, which is known to associate with chronic inflammation, destabilization of blood vessels, and aging.5 We therefore hypothesized that developing a recovery regimen based on an angiopoietin-1-derived peptide and a suitable ECM component