INTRODUCTION
MAging visibly affects the skin appearance and is due to two main factors: environmental (extrinsic) and genetic (intrinsic), resulting in decreased dermal thickness and diminished fibroblast activity of the aging skin. UV exposure specifically reduces collagen synthesis and causes its degeneration.1,59
Therefore, the main goal for correction of the skin thickening is to successfully stimulate collagen and elastin synthesis in the dermis. Various energy-base devices (EBD) (thermal, light, infrared, radio-frequency) can stimulate collagen synthesis and tightening leading to thicker and firmer skin, whilst restoring elastin with the EBD has not been definitely demonstrated yet. Micro-needling, dermal fillers, dermal threads and platelet rich plasma have been also reported as effective for wrinkles reduction and tightening effect.1-3
Jet Volumetric Remodeling (JVR) utilizes the principle of superficial soft tissue delivery of fluids, such as hyaluronic acid and other therapeutic materials. A pneumatically accelerated jet penetrates the epidermis through a small entry point and immediately disperses the fluid in a 3-D way.4,42 The accelerated dispersion of the fluid particles creates multiple nano-traumas to the surrounding tissues fibers (Figure 1). An activated repair results in dermal thickening and strengthening over time.5 JVR technology (EnerJet, PerfAction Technologies, Rehovot, Israel) accurately controls depth and volume of the delivery allowing for optimal penetration and distribution as needed through the treatment.
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There are a growing number of publications describing clinical efficacy of JVR method in skin thickening and other aesthetic indications. The aim of this paper is to review JVR delivery of hyaluronan in comparison to current skin remodeling treatment modalities.
Biological Effect
Progressive degrading of collagen and elastin fibers results in gradual reduction in dermis thickness and reduced density of retinacula cutis.6,7 EBDs promote collagen remodeling through
Therefore, the main goal for correction of the skin thickening is to successfully stimulate collagen and elastin synthesis in the dermis. Various energy-base devices (EBD) (thermal, light, infrared, radio-frequency) can stimulate collagen synthesis and tightening leading to thicker and firmer skin, whilst restoring elastin with the EBD has not been definitely demonstrated yet. Micro-needling, dermal fillers, dermal threads and platelet rich plasma have been also reported as effective for wrinkles reduction and tightening effect.1-3
Jet Volumetric Remodeling (JVR) utilizes the principle of superficial soft tissue delivery of fluids, such as hyaluronic acid and other therapeutic materials. A pneumatically accelerated jet penetrates the epidermis through a small entry point and immediately disperses the fluid in a 3-D way.4,42 The accelerated dispersion of the fluid particles creates multiple nano-traumas to the surrounding tissues fibers (Figure 1). An activated repair results in dermal thickening and strengthening over time.5 JVR technology (EnerJet, PerfAction Technologies, Rehovot, Israel) accurately controls depth and volume of the delivery allowing for optimal penetration and distribution as needed through the treatment.
There are a growing number of publications describing clinical efficacy of JVR method in skin thickening and other aesthetic indications. The aim of this paper is to review JVR delivery of hyaluronan in comparison to current skin remodeling treatment modalities.
Biological Effect
Progressive degrading of collagen and elastin fibers results in gradual reduction in dermis thickness and reduced density of retinacula cutis.6,7 EBDs promote collagen remodeling through
