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Dec 10
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Cutaneous Manifestations of EGFR-Inhibitors in African Americans and Treatment Considerations

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INTRODUCTIONTargeted therapies in particular epidermal growth factor (EGFR)-inhibitors have emerged as the primary therapy in advanced solid tumor malignancies including colorectal, pancreas, head and neck cancers, and non-small cell lung…
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Dec 10
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Human Pharmacokinetics and Safety of Subcutaneous Collagenase Clostridium Histolyticum in Women

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INTRODUCTIONCellulite is a localized alteration of skin topography (eg, dimpling) and affects 80% to 98% of postpubertal women of all ages and ethnicities.1,2 Although the pathophysiology of cellulite has not…
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Dec 10
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Efficacy and Safety of Intense Pulsed Light With a KTP/PDLlike Filter for the Treatment of Facial Telangiectasias

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INTRODUCTIONTelangiectasias are small blood vessels, typically measuring 0.1 to 1.0 mm in diameter, which may be of venular, capillary, or arteriolar origin.1,2 Telangiectasias develop secondary to a variety of factors…
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Dec 10
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Safety, Pharmacokinetics, and Efficacy of Efinaconazole 10% Topical Solution for Onychomycosis Treatment in Pediatric Patients

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INTRODUCTIONOnychomycosis—a chronic and recurring fungal infection of the fingernails or toenails—can occur in children, ranging in prevalence from 0.35%–5.5% worldwide.1 Though less common in children than adults,1 onychomycosis has been…
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Dec 10
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Biological Effects of Hyaluronic Acid-Based Dermal Fillers and Laser Therapy on Human Skin Models

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INTRODUCTIONInjection of hyaluronic acid (HA) dermal fillers is one of the most frequently performed aesthetic procedures.1 HA fillers exist in many different formulations differing in HA concentration, particle size and…
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Dec 10
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Randomized, Double-Blinded, Split-Face Study Comparing the Efficacy and Tolerability of Two Topical Products for Melasma

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INTRODUCTIONMelasma is a common, acquired disorder of skin hyperpigmentation that characteristically presents with symmetric brown macules and patches on the cheeks, forehead, and chin. The highest prevalence is seen in…
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Dec 10
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Prospective Analysis in Patients With HAE Under Prophylaxis With Lanadelumab: A Real-life Experience

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INTRODUCTIONPatients suffering from the bradykinin-induced genetic disease hereditary angioedema (HAE) show recurrent swelling of subcutaneous and submucosal structures. The attacks can affect almost every part of the body and may…
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Dec 10
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Hyaluronidase in Dermatology: Uses Beyond Hyaluronic Acid Fillers

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BACKGROUNDHyaluronidase is an enzyme used in ophthalmic surgery and dermatology. Its use is well-established and is the standard approach in dissolving Hyaluronic acid (HA) fillers (off-label) both in overcorrection and…
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Dec 10
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Clinical Relevance of Skin Pain in Atopic Dermatitis

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INTRODUCTIONAtopic dermatitis (AD) is a skin disorder characterized by chronic relapsing pruritic eczema resulting from altered skin barrier function and neuroimmune dysregulation.1 Moderate-to-severe AD can result in functional impairment, sleep…
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Dec 10
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Development and Evaluation of an Atopic Dermatitis Care Plan for Providers

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INTRODUCTIONAtopic Dermatitis (AD) is a common, chronic, inflammatory dermatosis and skin disease that follows a relapsing pattern and requires a dynamic and stepwise approach to management.1,2 AD is often associated…
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Dec 10
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Hydrogen Peroxide Topical Solution, 45% for Common Warts: Phase 2 Efficacy and Safety Trial Results

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INTRODUCTIONCommon warts, also known as verruca vulgaris, are benign skin and mucosal growths caused by human papillomavirus (HPV) infection of keratinocytes.1 Common warts can occur at virtually any anatomic location,…
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Dec 10
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Topical Agents Currently in Phase II or Phase III Trials for Atopic Dermatitis

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INTRODUCTIONAtopic dermatitis (AD) is a pruritic, inflammatory skin disease that affects approximately 5–30% of children and 2–10% of adults.1-3 The pathogenesis of AD involves a complex interplay of skin barrier…
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