When today’s dermatology residents were born, the concept of psoriasis as a systemic disease was relatively new. Early in the 1980s, topical therapy was the mainstay for medical management of…
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ARTICLE: IL-23 Versus IL-17 in the Pathogenesis of Psoriasis: There Is More to the Story Than IL-17A
INTRODUCTIONOur understanding of psoriasis pathogenesis has evolved over time. Before the 1980s, psoriasis was viewed as a skin-limited disease and the therapeutic mechanisms of commonly used treatments were not well…
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INTRODUCTIONEPIDEMIOLOGY, CLINICAL AND HISTOLOGIC FEATURES, AND QUALITY OF LIFE Melasma Melasma is an acquired disorder of hyperpigmentation that most commonly presents as symmetrically distributed brown to gray macules and coalescent…
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BACKGROUNDTreatment of moderate-to-severe psoriasis often poses a challenge to the physician.1 Patients with widespread disease frequently fail to respond to initial topical treatments and phototherapy and quickly move to the…
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INTRODUCTIONSelecting a systemic therapy for a patient with psoriasis is a complex process, based on a variety of factors including psoriasis severity, comorbid health conditions, access to care, and both…
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INTRODUCTIONTopical corticosteroid ointments, creams, and lotions are efficacious treatments for multiple dermatoses.1 However, adherence to these treatments is often abysmal.2,3 Individualizing treatments based on patient preference may improve adherence, patient…
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INTRODUCTIONPsoriasis is a chronic immune mediated disease of inflammatory dermatosis that affects 3.2% of adults in the United States and leads to a significant reduction in quality of life.1 The…
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INTRODUCTIONCutaneous fungal infections account for 3.5 to 6.5 million office visits per year1 – despite being common, their diverse presentations frequently lead to misdiagnosis.2,3 In one study, only 4 out…
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INTRODUCTIONAtopic dermatitis (AD) is a clinically defined, chronic skin condition characterized by intense itch, disruption of the skin barrier, and upregulation of type 2 immune responses.1-3 The disease has an…
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INTRODUCTIONPsoriasis is a life-long disease with a chronic relapsing course, with most patients requiring long-term management. However, disease evolution is unpredictable, with the extent of skin involvement and time between…
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INTRODUCTIONGuttate psoriasis is an acute subtype of plaque psoriasis characterized by eruption of small, scaly plaques, and papules, 5 to 10 mm in size over the trunk and proximal extremities.1…
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