Novartis and Secukinumab (AIN457)Novartis has announced results from the head-to-head Phase III psoriasis study which showed the superiority of secukinumab (AIN457) in clearing skin to Enbrel®* (etanercept), an anti-tumor necrosis…

Interleukin-12 Gene and in Vivo Electroporation- Mediated Plasmid DNA Vaccine Therapy in Treating Patients With Merkel Cell CancerSponsored by OncoSec Medical Incorporated in collaboration with National Cancer Institute, patients receive…

IntroductionThe August issue of JDD and this October issue are both dedicated to psoriasis, a cutaneous disorder teaching us the human immune system and the molecular biology of the epidermis.…

The T-cell disorders psoriasis and celiac disease are epidemiologically linked to atrial fibrillation (AF), a known inflammatory and fibrotic disorder.1,2 Indirect evidence has emerged for a humoral autoimmune pathogenesis for…

Actinic keratoses (AKs) and superficial non-melanoma skin cancers (NMSCs), such as basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs), are commonly encountered skin conditions. AK is a precancerous skin…

We appreciated the interesting case report by Wu et al,1 about a possible interaction between adalimumab and duloxetine and/or pregabalin. In the case, a 22 year old woman with type…

INTRODUCTION Adherence to treatment of chronic skin diseases is important to treatment outcomes. In the treatment of psoriasis,adherence is poor, with reported rates between 22% to 67%.1 However, adherence may…

INTRODUCTION Psoriasis is a chronic, immune-mediated, systemic inflammatory disease afflicting 0.6 to 4.8% of the population.1;2 There is no cure for the disease, necessitating lifelong treatment for management of the…

INTRODUCTION Psoriasis is a chronic inflammatory condition affecting 3% of the United States population.1 While most cases are mild and are successfully managed with topical medications, 17% of patients have…

INTRODUCTION The structural integrity, functional capacity, and regenerative potential of the human skin are known to be influenced, to a variable extent, by a plethora of factors, which thus greatly…

INTRODUCTION Ustekinumab (Stelara® Janssen Biotech, Inc., Horsham,PA), a human, monoclonal antibody that binds the shared p40 subunit of interleukin (IL)-12 and IL-23, is approved for the treatment of moderate-to-severe chronic…

INTRODUCTION Turmeric is a spice derived from the plant Curcuma Longa, used for centuries in food coloring, cooking, cosmetics, and as a medicinal remedy in the Ayurvedic system of medicine.…