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Dec 10
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Periocular Hyperpigmentation: A Review of Etiology and Current Treatment Options

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INTRODUCTIONFor dermatologists, periocular “dark circles” fall among the most difficult complaints to address. In most cases, we have little information regarding etiology and no gold-standard treatment option. For patients, periocular…
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Dec 10
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Failure of Alefacept in the Treatment of Vitiligo

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INTRODUCTIONVitiligo is a common acquired pigmentary disorder with a profound psychological impact. It has been reported to affect approximately 1% of the population worldwide, irrespective of skin color or ethnic…
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Dec 10
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Postoperative Wound Care After Dermatologic Procedures: A Comparison of 2 Commonly Used Petrolatum-Based Ointments

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INTRODUCTIONPostoperative wound care is important to promote rapid, uncomplicated healing. Principles of topical postoperative wound management include protecting the wound and keeping the wound surface clean and lubricated. A common…
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Dec 10
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Efficacy and Safety of Ustekinumab in Chinese Patients With Moderate to Severe Plaque-type Psoriasis: Results From a Phase 3 Clinical Trial (LOTUS)

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INTRODUCTIONPsoriasis is a chronic, immune-mediated skin disease affecting approximately 1% to 3% of the world’s population1; however, in China, the estimated prevalence is lower, at approximately 0.12% to 0.47%.2-4 Topical…
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Dec 10
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Combined Fractional Ablative and Nonablative Laser Resurfacing Treatment:A Split-Face Comparative Study

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INTRODUCTIONSkin resurfacing to rejuvenate photoaged skin and improve the appearance of facial wrinkles was first reported by Fitzpatrick et al1 using an ablative, pulsed carbon dioxide (CO2) laser. The erbium…
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Dec 10
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Randomized, Controlled, Evaluator-Blinded Studies Conducted to Compare the Efficacy and Tolerability of 3 Over-the-Counter Acne Regimens in Subjects With Mild or Moderate Acne

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INTRODUCTIONAcne vulgaris (acne) is commonly found in adolescents and young adults and presents as open and closed comedones, papules, pustules, nodules, and cysts most frequently affecting the face, neck, and/or…
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Dec 10
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Efinaconazole Solution in the Treatment of Toenail Onychomycosis: A Phase 2, Multicenter, Randomized, Double-Blind Study

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INTRODUCTION Onychomycosis is a progressive fungal infection of the nail bed, matrix, or plate that may lead to destruction and deformity of the toenails or fingernails.1,2 It is a common…
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Dec 10
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Skin Cancer in Skin of Color: An Update on Current Facts, Trends, and Misconceptions

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INTRODUCTIONFor people of color, skin cancer may not be top of mind as a significant health threat. However, while uncommon in darker complexions, skin cancer does occur and can be…
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Dec 10
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Are We Too Cavalier About Antiviral Prophylaxis?

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INTRODUCTIONMillions of Americans seek elective cosmetic procedures for the treatment of dyschromia, allergy/sensitivity, abscess, scabbing/skin necrosis, scars, dynamic and static rhytids, actinic damage, and other stigmata associated with the aging…
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Dec 10
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Progressive Multifocal Leukoencephalopathy and Reversible Progressive Leukoencephalopathy Syndrome in Dermatologic Therapy

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INTRODUCTION Progressive multifocal leukoencephalopathy (PML) is a rare but usually fatal demyelinating neurodegenerative disease. It occurs almost exclusively in individuals with severe immunodeficiencies, such as transplant recipients on immunosuppressant medications…
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Dec 10
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Elevated Serum Leptin Levels in Nonobese Patients With Psoriasis

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INTRODUCTION Psoriasis is a complex chronic inflammatory skin disorder affecting approximately 2% to 3% of the population, and it poses a lifelong burden for those affected. There is increasing awareness…
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Dec 10
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Role of 5α-Reductase Inhibitors in Androgen-Stimulated Skin Disorders

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INTRODUCTION Serum testosterone is the main serum androgen and stimulates the in utero differentiation of the Wolffian duct into male internal genitalia and the pubertal development of libido, enlargement of…
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