Just 10 years ago, studies were being published on biologics for psoriasis, new promising steps forward. At that time, one author wrote that biologics “provide only modest efficacy compared with…

INTRODUCTION The efficacy of ustekinumab in treating psoriasis has been demonstrated in Phase I through Phase III trials.1-6 Ustekinumab is a human monoclonal antibody that binds to the shared p40…

INTRODUCTION Janus kinases are a key component of the molecular machinery involved in signal transduction through various cytokine receptors.1 Janus kinases, which are associated with the cytoplasmic domain of cytokine…

INTRODUCTION Acne is a chronic condition with a prolonged course, slow onset, acute outbreaks, and a pattern of recurrence and relapse.1,2 Acne can have psychological and social consequences, 3 like…

INTRODUCTION Psoriasis is a T-lymphocyte (T-cell) mediated inflammatory skin disorder with an estimated prevalence of 1% to 3%,1 with up to one-third of affected individuals exhibiting moderate to severe disease.2…

INTRODUCTION Psoriasis is a common skin disease with a significant negative impact on health as well as quality of life and cumulative life course.1,2,3 In addition to systemic co-morbidities and…

INTRODUCTION Psoriasis is a chronic, inflammatory, immune-mediated disease of the skin that is often associated with co-morbidities such as depression, psoriatic arthritis, diabetes, and cardiovascular disease.1-5 Psychosocial co-morbidities, which may…

INTRODUCTIONPsoriasis is a chronic, genetically determined, immune-mediated inflammatory skin disease affecting approximately 2% to 3% of the Caucasian population. Plaque type is the most common form, even though other forms…

INTRODUCTION As the baby-boomer generation (born between 1945 to 1965) has aged, the older adult population has become a prominent age group in the United States (US) and is expected…

INTRODUCTION Disorders of hyperpigmentation including melasma, solar lentigines, ephelides, postinflammatory hyperpigmentation (PIH), mottled pigmentation, and dyschromia of photo-aging are conditions commonly seen in clinical dermatology practices. These pigmentary disorders can…

INTRODUCTION Herpes labialis is an exceedingly common condition caused by episodic reactivation of latent herpes simplex virus, type 1 (HSV-1) leading to recurrent painful and socially embarrassing lesions (cold sores).1-5…

INTRODUCTION Cyclosporine is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It forms a complex with cyclophilin, a cytoplasmic immunophilin. This complex inactivates calcineurin phosphorylase, preventing the phosphorylation…