INTRODUCTION Atopic dermatitis (AD) is a common, chronic inflammatory skin disease that presents with markedly pruritic eczematous lesions in highly characteristic distribution patterns in infants and children. Symptoms begin during…

INTRODUCTION Landsteiner and Chase are generally credited with the first conscious discovery of cell-mediated immunity (CMI) with the contact sensitizer picryl chloride (PCL) in 1942. Peritoneal exudate, which is what…

INTRODUCTION Atopic dermatitis (AD) is one of the most common inflammatory diseases, affecting up to 13 million children in the United States alone in 2009.1 The economic impact of AD…

INTRODUCTION Ingenol mebutate (ingenol-3-angelate), derived from the sap of the plant Euphorbia peplus, is a highly bioactive diterpene ester with cytotoxic and immune-stimulatory activity.1-3 Numerous studies have evaluated the biological…

INTRODUCTION Seborrheic dermatitis and atopic dermatitis are well recognized as common facial dermatoses. Both irritant and allergic contact dermatitis may involve any anatomic location, with facial involvement sometimes noted depending…

INTRODUCTION By 1970, systemic corticosteroids, the mainstay therapy of patients with pemphigus vulgaris, had reduced the disease's mortality rate from nearly 100% to approximately 24%.1 The addition of “adjuvant,” corticosteroid-sparing…

INTRODUCTION Over the past ten years, several biologic agents have been marketed following randomized controlled trials in patients with psoriasis for the indication of plaque psoriasis and/or psoriatic arthritis1,2 for…

INTRODUCTION Rosacea is a chronic inflammatory facial dermatosis that is typically characterized by a pattern of unpredictable exacerbations and remissions. The highest incidence of rosacea occurs in people of Celtic…

INTRODUCTION Discoid lupus erythematosus (DLE) is a chronic inflammatory disorder mediated by Th (helper)-1 cells.1 Apremilast blocks the degradation of cyclic adenosine monophosphate (cAMP) via inhibition of the phosphodiesterase (PDE)…

INTRODUCTION Warts are a common viral infection affecting an estimated 20% of children.1 Therapy for treatment-resistant warts with squaric acid dibutyl ester (SADBE) in acetone, consists of sensitizing with 1%…

BACKGROUND JFAP Miller discovered the thymic education of T-cell clones in 1961. In 1962, the British leprologists classified leprosy according to the thymus as intact cell-mediated immunity (CMI) tuberculoid and…

CASE REPORT A white female, aged 22 years, with severe pustular psoriasis and psoriatic arthritis since the age of 14 years had recalcitrant disease and presented for further treatment options.…