A Novel Four-Step Regimen is Efficacious in Improving Uneven Skin Tone in Sensitive Skin Patients

December 2024 | Volume 23 | Issue 12 | 1072 | Copyright © December 2024


Published online November 25, 2024

doi:10.36849/JDD.8220

Thu Q. Nguyen PhD, Christine Emesiani PharmD, Matthew Meckfessel PhD

Galderma Laboratories, LP, Dallas, TX

Abstract
Background: The appearance of dull skin, uneven skin tone, dark spots, and hyperpigmentation is often bothersome, especially in individuals with darker skin tones. Management of skin dyschromia can be difficult. Several topical ingredients, such as niacinamide and vitamin C, are clinically proven to inhibit pigmentation formation and improve overall skin tone. A skincare regimen formulated to minimize irregular melanin deposition levels has been specifically developed to help improve uneven skin tone for a more radiant appearance. This regimen consists of an exfoliating cleanser (EC), an antioxidant C serum (ACS), a day cream with SPF (DC), and a renewing cream (RC).
Methods: A 12-week in-use clinical regimen study was conducted to assess the efficacy, tolerability, and consumer perception of these products on 43 subjects with mild-to-moderate uneven skin tone. Assessments included clinical photography, tolerability, and a self-assessment questionnaire.
Results: There was a noticeable improvement in uneven skin tone, as shown in clinical photography across all timepoints (weeks 4, 8, and 12) compared to baseline. The regimen was safe and well tolerated for use and was highly acceptable among the subjects, with 81% of participants agreeing that their skin was more radiant since initiation of the regimen and 76% agreeing that the regimen had helped to significantly reduce the appearance of dark spots after 12 weeks of use. There were no reported adverse events.
Conclusion: Overall, these data show that this regimen is effective in reducing the appearance of uneven skin tone.

J Drugs Dermatol. 2024;23(12):1072-1075. doi:10.36849/JDD.8220

INTRODUCTION

Uneven skin tone is a significant beauty concern for individuals across all types of Fitzpatrick skin types and ethnic heritages, although it may be a more prominent concern for those with more darkly pigmented skin.1,2 Even skin color is associated with attractiveness and youth in those with lighter or darker skin.1 Changes in skin tone may be at least partially due to variability in environmental differences and geographical locations.1 Behavioral habits can also contribute to overall skin aging and radiance. Unfortunately, there currently are limited options to manage pigmentary problems. In addition, some consumers may have only limited access to dermatology specialists. One important modifiable factor in optimizing skin tone and radiance may be to use skincare regimens that have been specifically formulated to improve skin resilience and reduce discolorations. For individuals who have dyspigmentation along with sensitive skin, it is essential to select skincare regimens that are gentle and well tolerated.

Sensitive skin, defined as a negative sensory reaction associated with environmental factors as well as contact with specific ingredients, often without visible clinical manifestations, is surprisingly common. In a recent review, Duarte et al reported that 38.4% of the world’s population have sensitive skin, and, further, rates of sensitive skin in women hover around 50% depending on geographic region.3 In the United States, a rate of 44.6% has been reported for sensitive skin.3 Consumers with sensitive skin seek solutions for hyperpigmentation that won’t damage the skin barrier and are both safe and effective. Some current hyperpigmentation/uneven skin tone products on the market contain ingredients like acids at high percentages that may not be reasonable for a sensitive skin patient. Indeed, cosmetics are prominent triggering factors of sensitive skin, especially in women.3 A number of substances have the potential to cause irritation, including alpha-hydroxy acids, propylene glycol, alcohol, and fragrances, among others.3 Additionally, products that raise or lower the normal pH of the skin can compromise barrier function, allowing penetration of substances and an irritant response.3

This study was designed to assess the effect of a healthy radiance (HR) skin regimen (Cetaphil Gentle PHA Exfoliating cleanser [EC], Antioxidant-C Serum [ACS], Whipped Day Cream with SPF 30 [DC], and Renewing Cream [RC] at night; Galderma