New Insights into Imiquimod’s Mechanisims of Action

May 2004 | Volume 3 | Issue 3 | Original Article | 247 | Copyright © May 2004

Rafael F. Martin-Garcia, MD

Imiquimod, an immune response modifier with potent antiviral and antitumor properties, has been reported to be effective in the treatment of various cutaneous neoplasms. Besides stimulating the production of pro-inflammatory cytokines through Toll-like receptors on the surface of dendritic cells of monocyte-macrophage lineage, novel antiapoptotic mechanisms have been identified.