Neurocosmetic Post-Procedure Cream for Reducing Patient Discomfort and Enhancing Lower Eyelid Recovery After Ablative Treatments

September 2025 | Volume 24 | Issue 9 | 952 | Copyright © September 2025


Published online August 31, 2025

doi:10.36849/JDD.8835

Kian Karimi MD FACSa, Sofia Iglesia MSb, LaRyel A. Waldon BSa, Angela Cong BSa, Tatiana Kononov BS MBAb, Alisar S. Zahr PhDb

aRejuva Medical Aesthetics, Los Angeles, CA
bRevision Skincare®, Irving, TX

Abstract
Contour Tunable Resurfacing Laser (TRL™) is an erbium: yttrium aluminum garnet (YAG) fully ablative laser commonly used to treat the delicate lower eyelid skin for undereye rejuvenation. Post-treatment patients experience discomfort and extensive downtime. This pilot study incorporated an innovative post-procedure treatment that addresses patient concerns to skin rejuvenation procedures to improve patient relief and recovery, while improving patient retention. The evaluated neurocosmetic Post Procedure Cream (PPC) was safe and tolerable for the thin delicate lower eyelid skin. Following Contour TRL™ under-eye rejuvenation, the PPC ameliorated discomfort by reducing erythema, edema, stinging, and itch post-treatment, while enhancing recovery. Tested alongside the commonly used anhydrous topical, the PPC reduced erythema in the treatment area better than the comparator after 3 days and restored skin tone evenness to pre-procedure condition as early as 7 days post-procedure and maintained skin health for 31 days. The PPC offers physicians a topical solution for post-laser rejuvenation, addressing an unmet need by reducing patient discomfort and enhancing skin recovery.

J Drugs Dermatol. 2025;24(9) doi:10.36849/JDD.8835

INTRODUCTION

Aglobal survey exposed that “fear of needles/injections/pain”, and “safety and side effects” were patients’ main barriers when seeking aesthetic procedures, while aesthetic physicians underestimated these as patient concerns.1 Skin rejuvenation procedures provide notable and desirable aesthetic results; however, patient discomfort and downtime reduce the likelihood that patients seek and/or complete the recommended treatment series.

The lower eyelid skin is a common area of concern as photoaging, visibly manifested as laxity, wrinkles, and pigmentation, appears earlier on the eyelids versus adjacent facial skin. Contour Tunable Resurfacing Laser™ (TRL) (Sciton, Inc., Palo Alto, CA) is an erbium: yttrium aluminum garnet (YAG) fully ablative laser that offers control over the depth of ablation and coagulation.2,3 Recommended Contour TRL™ post-procedure care includes a 48-hour application of petroleum jelly. A study on 7 subjects revealed that the average pain score post-Contour TRL was 4.0 out of 10 (0 = none, 10 = intolerable), with a downtime of 7 to 10 days and adverse effects included edema, erythema, and flaking.4

A topical skincare treatment that can be incorporated immediately post-procedure to alleviate patient discomfort, while enhancing skin recovery and reducing downtime is an unmet need. Addressing patient barriers to skin rejuvenation procedures may improve patient compliance while improving recovery time.

The skin is highly innervated with sensory receptors expressed on keratinocytes and sensory neurons that detect chemical, mechanical, and thermal stimuli, and relay this information to the brain through the skin-brain axis.5 Neurocosmetic ingredients modulate communication by activating or reducing the transmission of sensory information from the skin to the brain.6 A breathable, semi-occlusive, gas-permeable, skin lipid-based post-procedure cream (PPC) was formulated with phytocompounds that directly stimulate communication between the nervous system and the skin. The PPC, containing proprietary unique neurocosmetic technology, a postbiotic, and lipophilic and hydrophilic hydrators was developed to address and ameliorate patient barriers in seeking and completing aesthetic rejuvenation procedures.