Multiple Palmar Keratoacanthomas Treated with Acitretin

A 62-year-old female presented with multiple keratoacanthomas of the palmar aspects of the hands, wrists, and proximal fingers. Surgery or radiation therapy would have caused significant impairment. A 30-day course of 1 mg/kg per day of acitretin led to a complete resolution. Maintenance therapy with 25 mg per day of acitretin was needed to prevent recurrence. The medical treatment of keratoacanthomas is herein discussed as well.