Meeting Patient Expectations of Topical Psoriasis Treatment: Evidence Supporting the Use of Fixed-Combination Halobetasol/Tazarotene Lotion

February 2023 | Volume 22 | Issue 2 | 132 | Copyright © February 2023


Published online January 31, 2023

James Del Rosso DOa, George Han MDb, April Armstrong MDc, G. Michael Lewitt MDd, Abby Jacobson PA-Ce

aTouro University Nevada, Henderson, NV
bIcahn School of Medicine at Mount Sinai, New York, NY
cUniversity of Southern California, Los Angeles, CA
dIllinois Dermatology Institute, Chicago, IL
eOrtho Dermatologics (a division of Bausch Health US, LLC), Bridgewater, NJ

Abstract
Discordance between patient and clinician treatment goals and expectations can present a challenge to implementation of effective therapeutic plans. Because topical treatments are commonly used for plaque psoriasis, both as monotherapy and adjuncts to other treatment modalities, providers need to understand the concerns of patients with psoriasis regarding use of topical products. Psoriasis is a complex and chronic disease with treatment needs that may change over time, influencing patient treatment goals and expectations of efficacy. When these expectations are not met and patient concerns are unaddressed, dissatisfaction may lead to nonadherence, which in turn can prevent patients from achieving relief from the signs and symptoms of psoriasis that affect their quality of life.

Here, we detail how current topical treatments meet patient expectations and needs, with particular attention given to combination regimens using corticosteroids. This review shows that once-daily application of halobetasol propionate (0.01%) and tazarotene (0.045%) lotion (HP/TAZ) not only has a rapid onset of treatment effect and proven efficacy, but also has a remittive effect. In addition, HP/TAZ has a favorable safety profile, with low rates of irritation and local skin reactions in clinical studies. The dual mechanisms of action related to 2 active ingredients, once-daily use, and the favorable clinical findings suggest that HP/TAZ may address patient concerns and promote treatment adherence.

J Drugs Dermatol. 2023;22(2):132-138. doi:10.36849/JDD.7367

Citations: Del Rosso J, Han G, Armstrong A, et al. Meeting patient expectations of topical psoriasis treatment: Evidence supporting the use of fixed-combination halobetasol/tazarotene lotion. J Drugs Dermatol. 2023;22(2):132-138. doi:10.36849/JDD.7367 

INTRODUCTION

Topical treatments are often used both as initial monotherapy for more localized presentations of psoriasis and as adjunctive therapy for more severe disease.1-3 Topical medications focally target affected skin lesions, resulting in lower levels of systemic exposure and thus potentially fewer systemic adverse effects compared with systemic therapies.4 However, psoriasis is a complex and chronic disease, and symptoms, severity, and therapeutic needs may change over time. Thus, treatment is a lifelong challenge and concern. Over the course of their disease, it is common for patients with psoriasis to use multiple topical therapies.5 To effectively treat patients, clinicians must consider why previous treatments may have been inadequate and/or intolerable and recommend therapies that optimize therapeutic response for the individual patient.

Studies have suggested discordance between physician- and patient-reported treatment outcomes owing to misalignment of physician perceptions with patient preferences regarding treatment satisfaction.6,7 In a study of 80 individuals with psoriasis, correlation was weak between objective improvements in skin lesions (measured by psoriasis area and severity index) and patient-reported quality-of-life improvements (P=0.50).8 Greater concordance between physicians’ treatment recommendations and patient preferences may result in improved patient satisfaction. A commonly identified reason for patients to alter their therapeutic regimen is lack of effectiveness and symptom relief.5 Failure to achieve disease control that matches patient expectations may lead to poor adherence and decreased quality of life.6

Multiple factors influence patient satisfaction with treatment, including skin clearance, symptom relief, and ease of use. Occasionally, patients may be satisfied with less than a "clear" outcome if the treatment is easier to use or better tolerated.2 However, use of topical drugs may also be inconvenient and time-consuming;9 formulations that are messy and difficult