Keloidal Morphea: A Unique Variant of Morphea Presenting in a Black Female

February 2025 | Volume 24 | Issue 2 | 7960 | Copyright © February 2025


Published online January 10, 2025

doi:10.36849/JDD.7960

Nicole C. Syder MDa, Autumn L. Saizan MDb, Shanice McKenzie MDc, Brittney De Clerck MDc, Arielle Carolina Mora Hurtado BSd, Nada Elbuluk MD MScc

aDepartment of Dermatology, University of California San Francisco School of Medicine, San Francisco, CA
bDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD
cDepartment of Dermatology, Keck School of Medicine of the University of Southern California, Los Angeles, CA
dUniversity of Wisconsin School of Medicine and Public Health, Madison, WI

Abstract
Keloidal morphea is a rare variant of cutaneous scleroderma that presents with keloid-like plaques and nodules that occur most commonly on the neck, trunk, and proximal extremities. They occur in the absence of trauma or injury. Keloidal morphea most often manifests in patients with skin of color and may be mistaken for keloids and/or hypertrophic scars. This report presents a case of keloidal morphea in a young Black female. While effective therapies are limited, timely diagnosis can initiate the evaluation for systemic sclerosis and other systemic organ involvement. Increased awareness and recognition of keloidal morphea can help prevent dermatologic health disparities, which disproportionately occur in patients of color.

J Drugs Dermatol. 2025;24(2): doi:10.36849/JDD.7960

CASE REPORT

A 26-year-old Black female with a history of Raynaud’s syndrome presented with complaints of a pruritic dermatitis on the right abdomen, right thigh, and chest. She noted that it first began on her right thigh 1.5 years prior and, more recently spread to her chest and neck. She denied any pain or tenderness or any prior dermatitis or trauma. She endorsed a family history significant for systemic lupus erythematous in her aunt.

Physical exam findings revealed dark brown to violaceous, smooth, well-demarcated, indurated, and hypertrophic plaques and dark brown patches on her upper chest, right neck, abdomen, right thigh, bilateral flanks, and suprapubic region.

A punch biopsy revealed marked cellular fibroplasia with a proliferation of capillaries and fibroblasts. CD34 staining showed a decrease in dermal dendritic cells. Histopathologic findings showed dermal fibroplasia, consistent with scar possibly related to keloid formation. Repeat biopsy revealed a diffuse fibrosing process with features of a hypertrophic scar and loss of the CD34 dermal dendritic cell network, as well as sclerosis into the subcutaneous septae. Through her combined clinical presentation and histopathology, she was diagnosed with keloidal morphea. Topical treatment was initiated with a combination of topical clobetasol and calcipotriene cream with a plan to add intralesional steroid injections. The patient was also advised to follow up with rheumatology for further