Irbesartan- Associated Persistant Edema of the Eyelids, Face, and Neck

December 2002 | Volume 1 | Issue 3 | Case Reports | 329 | Copyright © December 2002

Philip R. Cohen, MD

Irbesartan, an angiotensin II receptor antagonist(AIIRA), is an antihypertensive agent that inhibits the activity of angiotensin II by selectively binding to angiotensin II type 1 (AT1) receptors. The new onset of sustained periorbital, facial, and neck edema following the initiation of irbesartan therapy is described in a hypertensive 52-year-old woman. The patient's edema was not life threatening, remained unchanged following discontinuation of the medication, and persisted when treatment with the drug was subsequently reinstituted. Facial edema is a very uncommon adverse event that may occur in patients receiving irbesartan.