INDIVIDUAL ARTICLE: Real-World Patient Cases Using Triple Lipid-Containing Cream for Cutaneous Healing Post Laser or Microneedling Radiofrequency Treatment

September 2024 | Volume 23 | Issue 9 | 68821s3 | Copyright © September 2024


Published online August 30, 2024

Michael Gold MD FAADa, Anneke Andriessen PhDb, Daniela Greiner-Krüger MDc, Edward Lain MD FAADd, Seunghee Lee MDe, Heewon Suh MDf, Cara McDonald MBBS BMedSci MPH FACDg, Steven Nisticò MD PhDh, Zaki Taher MD FRCPCi, Minfang Wang MDj, Patricia Brieva PhDk

aGold Skin Care Center, Nashville, TN
bUMC Radboud, Nijmegen, Andriessen Consultants, Malden, The Netherlands
cMedicorium Center for Dermatology and Aesthetics, Oberursel, Germany
dSanova Dermatology, Austin, TX
eYLAS Clinic, Busan, South Korea
fCheongdam Circle Clinic, Seoul, South Korea
gSt Vincent’s Hospital, Melbourne, Australia; hSapienza University of Rome, Italy
iUniversity of Alberta, Edmonton, Alberta, Canada
jYesSkin Cosmetic Clinic, Hangzhou, China; kSkinCeuticals, New York, NY

Abstract
Lipids play an essential role in skin barrier health. With age, there is a natural reduction of physiological lipids such as fatty acids, ceramides, and cholesterol. The triple lipid restore cream is a moisturizer that contains an optimized lipid ratio for aging skin. The cream contains a 2:4:2 ratio of ceramides, cholesterol, and fatty acids that have been shown to best support aging skin. The triple lipid restore cream has been used in combination with energy-based procedures, to provide patients with comprehensive integrated skincare regimens. With limited clinical data and guidelines available in regenerative medicine, real-world cases serve as an invaluable guide for patients and dermatologists in navigating rejuvenation treatment plans.

J Drugs Dermatol. 2024;23:9(Suppl 1):s3-14.

INTRODUCTION

According to the American Society of Plastic Surgeons, nonsurgical cosmetic procedures accounted for over 15 million cosmetic procedures performed in the United States in 2018.1  In addition, Google searches for awareness of anti-aging and skin resurfacing procedures have seen a rise.2  These procedures aim to combat the inevitable problem of skin aging and help to promote skin rejuvenation. 

Skin aging is a natural process that results from a build-up of oxidative stress and cumulative DNA damage, which result in increased skin laxity, wrinkling, xerosis, abnormal pigmentation, and dullness.3  Skin aging occurs due to both intrinsic and extrinsic factors. Intrinsic aging is a product of chronological age and genetic and hormonal factors.3 On the other hand, extrinsic aging is primarily a product of ultraviolet (UV) radiation, environmental chemicals, toxins, pollutants, diet, and comorbid illnesses.3 In addition, with age, there is a natural decline in skin lipids such as fatty acids and ceramides, putting older individuals at risk of dry skin and xerosis.3 

Skin Rejuvenation Using Energy-Based Devices (Lasers and Microneedling with Radiofrequency (MRF))
Since the invention of selective photo-thermolysis in the early 1980s, lasers and other energy-based technologies have transformed the field of cosmetic dermatology and anti-aging medicine.4  There are a variety of energy-based devices (EBD) that exist for skin rejuvenation, scar revision, collagen tightening, and correction of dyspigmentation.4 Laser resurfacing produces controlled skin injury to stimulate wound healing and collagen remodeling, which results in skin rejuvenation. EBD treatment falls into 2 categories: ablative and non-ablative laser skin resurfacing.4 
 
Ablative laser skin resurfacing can be achieved using high-energy CO2 or erbium lasers that target water in tissue, causing vaporization of the entire epidermis and partial dermis.4 These lasers are used to treat facial rhytids, atrophic scars, and various epidermal/dermal lesions by thermally ablating and vaporizing the epidermis and heating the dermis to tighten the skin bed.4 While ablative lasers provide the best clinical outcomes in a 
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