Image Analysis of Xerosis and Atopic Dermatitis Following Prebiotic Skincare Regimen in Ethnically Diverse Patients

July 2024 | Volume 23 | Issue 7 | 557 | Copyright © July 2024


Published online June 26, 2024

doi:10.36849/JDD.8371

Hawasatu Dumbuya PhDa, Zoe Diana Draelos MDb, Eva Cassar c, Charlotte Peucat c, Caroline Le Floc'h d, Katharine Podimatis MAa

aRoche-Posay Laboratoire Dermatologique, L'Oreal USA, New York, NY
bDermatology Consulting Services, PLLC, High Point, NC
cNewtone Technologies, Lyon, France 
dLa Roche-Posay Laboratoire Dermatologique, L'Oreal, Levallois-Perret, France

Abstract


Variations in the epidemiology, clinical presentation, and disease course in atopic dermatitis (AD) patients with Skin of Color (SOC) compared with white counterparts have been reported. In this study, we evaluated the capability of a new imaging device (SkinCam) in quantifying skin texture changes in diverse patients, presenting with AD or xerosis, after using a prebiotic skincare routine over 10 weeks.  A total of 39 subjects from diverse racial/ethnic backgrounds, aged 3 to 76 years old, with Fitzpatrick skin phototypes I to VI, presenting with mild AD and moderate to severe xerosis, were enrolled in the study. All subjects used a prebiotic cleanser on its own for 2 weeks, followed by a prebiotic moisturizer in conjunction for an additional 8 weeks. Standardized images of the subjects' legs were taken with SkinCam at several time points (baseline, week 2, and week 10), and analyzed for skin texture parameters. Our results demonstrate that both skin texture irregularity and skin color patterns significantly improve over time with a prebiotic skincare regimen in AD (n=12) and xerosis (n=24) subjects. Interestingly, image analyses showed more improvement over time in xerosis and AD SOC patients (n=18, Fitzpatrick IV-VI). Lastly, skin texture analyses from SkinCam imaging correlated with clinical assessments, showing significant improvement by prebiotic skincare regimen in all subjects by week 10. In summary, our results demonstrate that the SkinCam imaging device has the capability to effectively monitor skin texture parameters over time in both AD and xerosis patients with lightly and darkly pigmented skin. 

J Drugs Dermatol. 2024;23(7):557-563.  doi:10.36849/JDD.8371

INTRODUCTION

Dry skin, also known as xerosis, can be relatively asymptomatic or more pronounced, with inflammation and superficial cracking causing unpleasant itching, stinging, and general discomfort.1 Atopic dermatitis (AD), or eczema, is a common and heterogenous chronic relapsing inflammatory skin disease, characterized by eczematous and pruritic lesions, affecting both children and adults of diverse racial and ethnic groups.2,3  AD pathophysiology is multifactorial and involves gene predisposition, skin barrier dysfunction, environmental triggers, immune dysregulation, and microbial dysbiosis.2,4,5  

AD is also reported to have a higher incidence and prevalence in patients with skin of color (SOC).6-9 In the United States, African American children are 1.7 times more likely to develop AD than their European American counterparts.10,11  Treatment of dry skin or mild AD, among other modalities, involves using a gentle cleanser with an acidic pH to respect the acidic skin mantle, and regular use of moisturizers.12 However, given the physiological variations in skin among different races and ethnicities, plus age groups, an ideal moisturizer for one patient may be less useful for another.13