Generalized Necrobiotic Xanthogranuloma Successfully Treated With Lenalidomide

March 2010 | Volume 9 | Issue 3 | Case Reports | 273 | Copyright © March 2010

Sirunya Silapunt MD and Susan Y. Chon MD

Necrobiotic xanthogranuloma (NXG) presents a therapeutic challenge to clinicians. Generalized NXG has limited treatment options. A patient presented to the authors with generalized NXG associated with monoclonal gammopathy of unknown significance (MGUS), a plasma cell dyscrasia considered to be a precursor to multiple myeloma.

The patient was treated with lenalidomide, a derivative of thalidomide with efficacy in treatment of multiple myeloma. Resolution of paraproteinemia was associated with resolution of NXG.