Generalized Necrobiotic Xanthogranuloma Successfully Treated With Lenalidomide
March 2010 | Volume 9 | Issue 3 | Case Reports | 273 | Copyright © March 2010
Sirunya Silapunt MD and Susan Y. Chon MD
Abstract
Necrobiotic xanthogranuloma (NXG) presents a therapeutic challenge to clinicians. Generalized NXG has limited treatment options. A
patient presented to the authors with generalized NXG associated with monoclonal gammopathy of unknown significance (MGUS),
a plasma cell dyscrasia considered to be a precursor to multiple myeloma.
The patient was treated with lenalidomide, a derivative of thalidomide with efficacy in treatment of multiple myeloma. Resolution of paraproteinemia was associated with resolution of NXG.
