FULL SUPPLEMENT: Reevaluating Oral Antibiotic Use in Acne Management

November 2025 | Volume 24 | Issue 11 | 99180 | Copyright © November 2025


Published online October 31, 2025

ET AL

Abstract
Antibiotics remain a cornerstone in the management of dermatologic conditions such as acne and hidradenitis suppurativa, underscoring
the need for responsible antibiotic stewardship. This article explores the “dark side” of antibiotics, highlighting their role in disrupting
the gut microbiome, elevating risks for infections like Clostridium difficile, and increasing resistance in Cutibacterium acnes and other
microbes. Emerging evidence also links antibiotic use to reduced vaccine efficacy and diminished responses to cancer immunotherapy.
To mitigate these risks, dermatologists should prioritize narrow-spectrum antibiotics and incorporate combination topical therapies
containing benzoyl peroxide (BPO), such as the triple-combi
In this issue:

VEHICLES MATTER
Although data suggest that antibiotic use by dermatologists is decreasing, our specialty still has the highest rates of oral antibiotic prescribing across all fields of medicine.1,2 In an era of intense concern about antibiotic resistance...
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The Utility of Delgocitinib in Chronic Hand Eczema
Antibiotics remain a cornerstone in the management of dermatologic conditions such as acne and hidradenitis suppurativa, underscoring the need for responsible antibiotic stewardship.
Read more

Keywords: Supplement
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