The Emerging Role of Oncodermatology in a Hemato-Oncology Unit in a Tertiary Hospital

October 2025 | Volume 24 | Issue 10 | 8965 | Copyright © October 2025


Published online September 30, 2025

Rhiannon Nancarrow-Lei MBBS, Emily Durity MBBS, Yasmin Alfallouji MBBS, Claire Martyn-Simmons MBA, Evangelia Panagou MBBS

University College London Hospitals NHS Foundation Trust, London, United Kingdom

Abstract
Background: Our dermatology department consistently receives the largest proportion of internal on-call referrals from the Hematology-Oncology Department. Individuals with hematological malignancies are particularly susceptible to dermatologic conditions secondary to immunosuppression and multi-agent exposure, which can impact cancer therapy, leading to morbidity and mortality.
Methods: Our primary objective was to analyze the range of dermatologic conditions observed in patients with hematologic malignancies and to identify potential associations with anticancer therapies.
We conducted a retrospective, single-center review of acute hematology-oncology referrals to our on-call service between August 2020 and November 2022. Consultations were identified retrospectively through the on-call referral log.
Results: One hundred and thirty-four (134) patients were included. The most common diagnoses were cutaneous adverse drug eruptions (22%), leukemia or lymphoma cutis (13%), infections (13%), and acneiform eruptions (10%). Notably, cutaneous drug reactions were more prevalent in patients with myeloid neoplasms (32%). Acneiform eruptions predominantly occurred in patients with myeloid lineage malignancies.
Conclusion: Dermatology plays a vital role in providing consultative services to patients with hematology-oncology conditions. With the emergence of novel therapies, the landscape of dermatologic complications in this population is evolving. Consequently, the demand for dermatology expertise is expected to increase to facilitate prompt diagnosis and management and to ensure optimal patient outcomes.

INTRODUCTION

Oncodermatology is an emerging, growing field of Dermatology aiming to provide supportive care to cancer patients and to prevent unnecessary interruption of cancer treatment. Dermatologic conditions are increasingly prevalent among patients with hematological malignancies. Phillips et al reported that hemato-oncology patients were 6 times more like to receive dermatological consultations compared with patients with non-hematological malignancies.1 This occurrence can be attributed to factors such as immunosuppression and exposure to multiple therapeutic agents. In addition, the introduction of novel therapies is likely contributing to this trend. The impact of dermatologic disease on cancer treatment outcomes, along with its potential to cause significant morbidity and mortality, underscores the crucial role of oncodermatology in the care of patients with hematology-oncology conditions.

The primary objective was to quantify and analyze dermatologic conditions observed in patients with hematology-oncology diagnoses at a central London tertiary hospital. The secondary objective was to explore potential associations between these conditions and specific subtypes of hematologic malignancies, as well as the anticancer therapies employed.

MATERIALS AND METHODS

We conducted a retrospective, single-center review to analyze acute hematology-oncology referrals received by our on-call dermatology service between August 2020 and November 2022. Data were collected from inpatient notes, clinic letters, and histopathology reports available in the electronic patient record system.

RESULTS

A total of 134 patients were referred to the dermatology department from the hematology-oncology department. Patient ages ranged from 13 to 88 years, with a median age of 54 years. The cohort included 58 males and 76 females (male-to-female ratio, 1:1.3).

Hematologic malignancies were classified as lymphoid neoplasms (45%), myeloid neoplasms (29%), plasma cell dyscrasias (13%), Hodgkin lymphoma (6%), and other malignant or nonmalignant diagnoses (7%). The most common diagnosis